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Gene Review:

delta - copy 2

Streptococcus pyogenes

Cottagnoud, P. et al., van Hijum, S.A. et al., Hensler, M.E. et al.

Cottagnoud, Acosta, Cottagnoud, Pfister, Täuber,

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Disease relevance of delta

BMS 284756 penetrated well into inflamed meninges (44% +/- 11%) and produced good bactericidal activity (-0.82 +/- 0.22 Delta log(10) CFU/ml. h) in the treatment of experimental meningitis in rabbits due to a penicillin-sensitive strain [1].
Expression of lev in Escherichia coli resulted in an active FTF (Lev Delta 773His) that produced the same levan polymer [with only 2-3 % beta(2-->1-->6) branching points] as L. reuteri 121 cells grown on raffinose [2].

High impact information on delta

Lung compliance during mechanical ventilation was impaired after injection of wt GBS but not after injection of the Delta beta h/c mutant strain [3].
Even against a penicillin- and quinolone-resistant strain, BMS 284756 showed good bactericidal activity (-0.52 +/- 0.12 Delta log(10) CFU/ml. h) [1].

References

Efficacies of BMS 284756 against penicillin-sensitive, penicillin-resistant, and quinolone-resistant pneumococci in experimental meningitis. Cottagnoud, P., Acosta, F., Cottagnoud, M., Pfister, M., Täuber, M.G. Antimicrob. Agents Chemother. (2002) [Pubmed]
Biochemical and molecular characterization of a levansucrase from Lactobacillus reuteri. van Hijum, S.A., Szalowska, E., van der Maarel, M.J., Dijkhuizen, L. Microbiology (Reading, Engl.) (2004) [Pubmed]
Virulence role of group B Streptococcus beta-hemolysin/cytolysin in a neonatal rabbit model of early-onset pulmonary infection. Hensler, M.E., Liu, G.Y., Sobczak, S., Benirschke, K., Nizet, V., Heldt, G.P. J. Infect. Dis. (2005) [Pubmed]

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