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Gene Review:

delta - hypothetical protein

Streptococcus pyogenes

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Disease relevance of delta

The Delta subunit of RNA polymerase is required for virulence of Streptococcus agalactiae [1].

High impact information on delta

BMS 284756 monotherapy had a greater potency than the standard regimen of ceftriaxone and vancomycin (-0.49 +/- 0.08 Delta log(10) CFU/ml. h) against a penicillin-resistant strain (MIC, 4 mg/liter) [2].
The combination of ceftriaxone with trovafloxacin considerably improved the killing rates (-0.67 +/- 0.16 Delta log(10) CFU/ml. h) and was slightly superior to ceftriaxone with vancomycin (killing rate, -0.53 +/- 0. 22 Delta log(10) CFU/ml. h), the regimen most commonly used in clinical practice [3].
Effect of environmental factors on the relationship between concentrations of coprostanol and fecal indicator bacteria in tropical (Mekong Delta) and temperate (Tokyo) freshwaters [4].
The sanitary condition of rural drinking water in a Nile Delta village. II. Bacterial contamination of drinking water in a Nile Delta village [5].

References

The Delta subunit of RNA polymerase is required for virulence of Streptococcus agalactiae. Jones, A.L., Needham, R.H., Rubens, C.E. Infect. Immun. (2003) [Pubmed]
Efficacies of BMS 284756 against penicillin-sensitive, penicillin-resistant, and quinolone-resistant pneumococci in experimental meningitis. Cottagnoud, P., Acosta, F., Cottagnoud, M., Pfister, M., Täuber, M.G. Antimicrob. Agents Chemother. (2002) [Pubmed]
Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro. Cottagnoud, P., Acosta, F., Cottagnoud, M., Neftel, K., Täuber, M.G. Antimicrob. Agents Chemother. (2000) [Pubmed]
Effect of environmental factors on the relationship between concentrations of coprostanol and fecal indicator bacteria in tropical (Mekong Delta) and temperate (Tokyo) freshwaters. Isobe, K.O., Tarao, M., Chiem, N.H., Minh, l.e. .Y., Takada, H. Appl. Environ. Microbiol. (2004) [Pubmed]
The sanitary condition of rural drinking water in a Nile Delta village. II. Bacterial contamination of drinking water in a Nile Delta village. El Attar, L., Abdel Gawad, A., Khairy, A.E., El Sebaie, O. The Journal of hygiene. (1982) [Pubmed]

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