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MeSH Review

Lung Compliance

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Disease relevance of Lung Compliance


High impact information on Lung Compliance

  • Samples exposed to FeCl2 + H2O2 had significantly diminished surface tension lowering ability in vivo as indicated by their reduced ability to improve lung compliance of surfactant-deficient fetal rabbits [6].
  • Lung compliance, pulmonary function, surfactant pool size, glucose and FFA levels were significantly decreased in adrenalectomized animals [7].
  • Complete deficiency of SP-B in mice and humans results in lethal, neonatal respiratory distress syndrome and is characterized by a virtual absence of lung compliance, highly disorganized lamellar bodies, and greatly diminished levels of SP-C mature peptide; in contrast, lung structure and function in SP-C null mice is normal [8].
  • Lung morphology, surfactant proteins B-D, lung tissue, alveolar phospholipid pool sizes and composition, and lung compliance in SP-A(-/-) mice were unaltered [9].
  • Eighteen patients with progressive pulmonary dysfunction, diminished vital capacity (VC), and/or decreased static lung compliance (Cst) were treated with cyclophosphamide and corticosteroids for 1 year [10].

Chemical compound and disease context of Lung Compliance

  • The data show that conventional doses of furosemide can (1) cause metabolic alkalosis and reduce ventilation; (2) increase the PaCO2, which reflects changes in acid-base status and not changes in lung function; and (3) increase lung compliance, perhaps by decreasing lung water [11].
  • Our data show that alpha 1-AT treatment prevented the reduced lung compliance observed in the untreated hyperoxia-exposed neonatal rats, as well as the right ventricular hypertrophy and the associated vascular changes of medial hypertrophy of muscular arteries and muscularization of distal arteries [12].
  • The relative activities of three bronchoconstrictive mediators of anaphylaxis, prostaglandin (PG) D2, PGF2 alpha and histamine, were investigated in anesthetized dogs using two different measures of peripheral lung reactivity: resistance to flow through collateral airways (Rcoll) and dynamic lung compliance (Cdyn) [13].
  • 4 These results may suggest that TXA2 is responsible for the endotoxin-induced pulmonary arterial hypertension but that some other arachidonic acid derivative (prostaglandin F2 alpha) is responsible for the reduced lung compliance that follows the acute administration of E. coli endotoxin [14].
  • Therefore, we measured EELV, total lung resistance (RL), dynamic lung compliance (Cdyn), DE, and minute ventilation (VE) in anesthetized rats during normoxia and hypoxia (10% O(2)) before (control) and after administration of atropine or saline [15].

Biological context of Lung Compliance


Anatomical context of Lung Compliance

  • During the study, percent change from baseline of peak airway pressure, total lung compliance of the lung and chest wall, and blood lactate levels appeared to be significantly smaller in dogs pretreated with CoQ10 than in controls [21].
  • RESULTS: Endotoxin caused decreases in peripheral leukocyte counts, lung compliance, and arterial oxygen tension, and increases in the lung wet-to dry-weight ratio, polymorphonuclear cell counts in BALF, and albumin, C3a, C5a, tumor necrosis factor alpha, interleukin-1 beta, and thromboxane B2 concentrations in BALF [22].
  • Stimulation of pulmonary C-fibers (PCs) by capsaicin and of rapidly adapting receptors (RARs) by reduced lung compliance reflexly increases airway submucosal gland secretion in dogs [23].
  • In this genetic mouse model of obesity, the results suggested that respiratory complications associated with the obese phenotype, including rapid breathing pattern at baseline, diminished lung compliance, and abnormal respiratory muscle adaptations, are attenuated with prolonged leptin treatment [24].
  • Effects of atropine on the responses of rapidly adapting pulmonary stretch receptors and dynamic lung compliance to sodium cyanide-induced hyperpnea [25].

Associations of Lung Compliance with chemical compounds


Gene context of Lung Compliance


Analytical, diagnostic and therapeutic context of Lung Compliance


  1. Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha. Hardie, W.D., Bruno, M.D., Huelsman, K.M., Iwamoto, H.S., Carrigan, P.E., Leikauf, G.D., Whitsett, J.A., Korfhagen, T.R. Am. J. Pathol. (1997) [Pubmed]
  2. Pathophysiologic correlations in lymphoid interstitial pneumonia. Collie, D.D., Warren, P.M., Begara, I., Luján, L., Watt, N.J. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  3. Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury. Tokieda, K., Iwamoto, H.S., Bachurski, C., Wert, S.E., Hull, W.M., Ikeda, K., Whitsett, J.A. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  4. The effect oa a new anti-inflammatory drug, flurbiprofen, on the respiratory, haemodynamic and metabolic responses to E. coli endotoxin shock in the cat. Parratt, J.R., Sturgess, R.M. Br. J. Pharmacol. (1976) [Pubmed]
  5. Controlled trial of beclomethasone dipropionate by nebulization in oxygen- and ventilator-dependent infants. LaForce, W.R., Brudno, D.S. J. Pediatr. (1993) [Pubmed]
  6. Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties. Gilliard, N., Heldt, G.P., Loredo, J., Gasser, H., Redl, H., Merritt, T.A., Spragg, R.G. J. Clin. Invest. (1994) [Pubmed]
  7. Effect of fetal adrenalectomy on catecholamine release and physiologic adaptation at birth in sheep. Padbury, J., Agata, Y., Ludlow, J., Ikegami, M., Baylen, B., Humme, J. J. Clin. Invest. (1987) [Pubmed]
  8. Function of surfactant proteins B and C. Weaver, T.E., Conkright, J.J. Annu. Rev. Physiol. (2001) [Pubmed]
  9. Altered surfactant function and structure in SP-A gene targeted mice. Korfhagen, T.R., Bruno, M.D., Ross, G.F., Huelsman, K.M., Ikegami, M., Jobe, A.H., Wert, S.E., Stripp, B.R., Morris, R.E., Glasser, S.W., Bachurski, C.J., Iwamoto, H.S., Whitsett, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Improved pulmonary function in systemic sclerosis after treatment with cyclophosphamide. Akesson, A., Scheja, A., Lundin, A., Wollheim, F.A. Arthritis Rheum. (1994) [Pubmed]
  11. Furosemide decreases ventilation in young rabbits. Hazinski, T.A. J. Pediatr. (1985) [Pubmed]
  12. Alpha 1-antitrypsin protects neonatal rats from pulmonary vascular and parenchymal effects of oxygen toxicity. Koppel, R., Han, R.N., Cox, D., Tanswell, A.K., Rabinovitch, M. Pediatr. Res. (1994) [Pubmed]
  13. Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. Spannhake, E.W., Kadowitz, P.J., Kleeberger, S.R. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  14. Effect of dazoxiben, a specific inhibitor of thromboxane synthetase, on acute pulmonary responses to E. coli endotoxin in anaesthetized cats. Ball, H.A., Parratt, J.R., Zeitlin, I.J. British journal of clinical pharmacology. (1983) [Pubmed]
  15. Lung mechanics and end-expiratory lung volume during hypoxia in rats. Bonora, M., Vizek, M. J. Appl. Physiol. (1999) [Pubmed]
  16. Improvement in VA/Q distributions during inhalation of nitric oxide in pigs with methacholine-induced bronchoconstriction. Putensen, C., Räsänen, J., López, F.A. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  17. Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig. Underwood, D.C., Muccitelli, R.M., Luttmann, M.A., Hay, D.W., Torphy, T.J., Wasserman, M.A. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  18. Changes in pulmonary function during the diuretic phase of respiratory distress syndrome. Heaf, D.P., Belik, J., Spitzer, A.R., Gewitz, M.H., Fox, W.W. J. Pediatr. (1982) [Pubmed]
  19. Airways hyperreactivity and bronchoconstriction induced by vanadate in the guinea-pig. Nayler, R.A., Mitchell, H.W. Br. J. Pharmacol. (1987) [Pubmed]
  20. Acceleration of fetal lung maturation by aminophyllin in pregnant rabbits. Karotkin, E.H., Kido, M., Cashore, W.J., Redding, R.A., Douglas, W.J., Stern, L., Oh, W. Pediatr. Res. (1976) [Pubmed]
  21. Effects of coenzyme Q10 in hemorrhagic shock. Yamada, M. Crit. Care Med. (1990) [Pubmed]
  22. Effect of lidocaine pretreatment on endotoxin-induced lung injury in rabbits. Mikawa, K., Maekawa, N., Nishina, K., Takao, Y., Yaku, H., Obara, H. Anesthesiology (1994) [Pubmed]
  23. Cigarette smoke in lungs evokes reflex increase in tracheal submucosal gland secretion in dogs. Schultz, H.D., Davis, B., Coleridge, H.M., Coleridge, J.C. J. Appl. Physiol. (1991) [Pubmed]
  24. Leptin attenuates respiratory complications associated with the obese phenotype. Tankersley, C.G., O'Donnell, C., Daood, M.J., Watchko, J.F., Mitzner, W., Schwartz, A., Smith, P. J. Appl. Physiol. (1998) [Pubmed]
  25. Effects of atropine on the responses of rapidly adapting pulmonary stretch receptors and dynamic lung compliance to sodium cyanide-induced hyperpnea. Matsumoto, S., Yamasaki, M., Nagayama, T., Kanno, T., Shimizu, T. J. Auton. Nerv. Syst. (1993) [Pubmed]
  26. Effects of an antibody to interleukin-5 in a monkey model of asthma. Mauser, P.J., Pitman, A.M., Fernandez, X., Foran, S.K., Adams, G.K., Kreutner, W., Egan, R.W., Chapman, R.W. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  27. Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure. Krell, R.D., Chakrin, L.W., Christian, P., Giannone, E., McCoy, J., Osborn, R. J. Allergy Clin. Immunol. (1976) [Pubmed]
  28. Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. Duggan, M., McCaul, C.L., McNamara, P.J., Engelberts, D., Ackerley, C., Kavanagh, B.P. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  29. Partial liquid ventilation with and without inhaled nitric oxide in a newborn piglet model of meconium aspiration. Barrington, K.J., Singh, A.J., Etches, P.C., Finer, N.N. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  30. Influence of deflated and anaerobic conditions during cold storage on rat lungs. Fukuse, T., Hirata, T., Nakamura, T., Kawashima, M., Hitomi, S., Wada, H. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  31. Intra-amniotic endotoxin increases pulmonary surfactant proteins and induces SP-B processing in fetal sheep. Bachurski, C.J., Ross, G.F., Ikegami, M., Kramer, B.W., Jobe, A.H. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  32. Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Mizgerd, J.P., Lupa, M.M., Hjoberg, J., Vallone, J.C., Warren, H.B., Butler, J.P., Silverman, E.S. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  33. Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice. Clark, J.C., Weaver, T.E., Iwamoto, H.S., Ikegami, M., Jobe, A.H., Hull, W.M., Whitsett, J.A. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  34. Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood. Le Cras, T.D., Hardie, W.D., Deutsch, G.H., Albertine, K.H., Ikegami, M., Whitsett, J.A., Korfhagen, T.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  35. Absence of host tumor necrosis factor receptor 1 attenuates manifestations of idiopathic pneumonia syndrome. Shukla, M., Yang, S., Milla, C., Panoskaltsis-Mortari, A., Blazar, B.R., Haddad, I.Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  36. The effects of 5-hydroxytryptamine, histamine and acetylcholine on the reactivity of the lung of the anaesthetized dog. Dixon, M., Jackson, D.M., Richards, I.M. J. Physiol. (Lond.) (1980) [Pubmed]
  37. Amiodarone induced phospholipidosis. Biochemical, morphological and functional changes in the lungs of rats chronically treated with amiodarone. Riva, E., Marchi, S., Pesenti, A., Bizzi, A., Cini, M., Veneroni, E., Tavbani, E., Boeri, R., Bertani, T., Latini, R. Biochem. Pharmacol. (1987) [Pubmed]
  38. Terbutaline does not improve lung function in preterm rabbits. Fiascone, J.M., Hu, L.M., Vreeland, P.N. Am. J. Obstet. Gynecol. (1992) [Pubmed]
  39. Pulmonary involvement in mixed connective tissue disease. Derderian, S.S., Tellis, C.J., Abbrecht, P.H., Welton, R.C., Rajagopal, K.R. Chest (1985) [Pubmed]
  40. Stellate ganglion stimulation with alpha and beta adrenergic blockade: effect on lung lipids and compliance in cats. Crittenden, D.J., Beckman, D.L. Life Sci. (1984) [Pubmed]
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