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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Meninges

  • Since acute fat embolism may produce lesions not only in the white matter of the brain, but also in the cord, the retina, the meninges, and the skin, and since all these have been described in MS, subacute fat embolism may be the cause of MS [1].
  • Although PGDS has been identified recently in rat leptomeninges, little information is available about human meninges or meningiomas [2].
  • SJL IL-10(-/-) mice with high numbers of PLP(139-151)-specific precursors in the repertoire did not develop spontaneous EAE, but when they were injected with pertussis toxin, they showed atypical clinical signs of EAE with small numbers of typical mononuclear cell infiltrates predominantly in the meninges [3].
  • Nonabsorptive hydrocephalus may have resulted from deposition of cystine in the meninges [4].
  • BACKGROUND: We postulated a model in which cell-free CSF virions originate from two major sources, namely, systemic non-CNS and CNS tissues, the latter including brain parenchyma and meninges [5].

Psychiatry related information on Meninges


High impact information on Meninges


Chemical compound and disease context of Meninges


Biological context of Meninges


Anatomical context of Meninges

  • By 6 months of age, MRL/Mp-lpr/lpr mice developed prominent mononuclear cell infiltrates restricted to the choroid plexus and meninges, whereas congeneric MRL/Mp- +/+ mice (which lack the lpr gene) showed delayed but widespread inflammatory infiltrates involving cerebral vessels and meninges, with sparing of the choroid plexus [22].
  • Some MBP-CFA-challenged resistant rats showed minimal inflammation in the central nervous system, which was, however, confined to the meninges of the lower spinal cord [23].
  • MRI showed a marked enhancement throughout her meninges and ependyma, and TTR amyloid deposition was confirmed by meningeal biopsy [24].
  • The IL-1 beta-induced increases in vessel permeability in the meninges, parenchyma, and choroid plexus were polymorphonuclear neutrophil dependent, since leukocyte depletion by irradiation or polymorphonuclear neutrophil anti-serum pre-treatment eliminated the response in the juvenile animals and in the adults [19].
  • Prior studies have documented these concentrations of cefamandole in cerebrospinal fluid in the presence of inflamed meninges [25].

Associations of Meninges with chemical compounds


Gene context of Meninges

  • Finally, the administration of neutralizing mAb specific for TNF-alpha and GM-CSF increased mortality in C. neoformans-infected mice, and induced the rapid progression of disease with involvement of the brain and meninges [31].
  • Finally, histological examination in hydrocephalic mice undergoing HGF treatment revealed reduction of collagen fibers in the meninges and normalization of their structures [32].
  • Finally, pattern formation requires the integrity of the external limiting membrane, defects of which lead to overmigration of neurons in meninges and to human type 2 lissencephaly [33].
  • A recent study on the relative disappearance of MAG versus MBP in primary and recurrent lesions of Theiler's infection had shown that numerous mononuclear cells in meninges and perivascular spaces specifically bound anti-MAG antibody [34].
  • During embryonic brain development, Hlf expression was restricted to the anterior pituitary and meninges [35].

Analytical, diagnostic and therapeutic context of Meninges


  1. Evidence for subacute fat embolism as the cause of multiple sclerosis. James, P.B. Lancet (1982) [Pubmed]
  2. Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. Yamashima, T., Sakuda, K., Tohma, Y., Yamashita, J., Oda, H., Irikura, D., Eguchi, N., Beuckmann, C.T., Kanaoka, Y., Urade, Y., Hayaishi, O. J. Neurosci. (1997) [Pubmed]
  3. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. Anderson, A.C., Reddy, J., Nazareno, R., Sobel, R.A., Nicholson, L.B., Kuchroo, V.K. J. Immunol. (2004) [Pubmed]
  4. Nonabsorptive hydrocephalus associated with nephropathic cystinosis. Ross, D.L., Strife, C.F., Towbin, R., Bove, K.E. Neurology (1982) [Pubmed]
  5. Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources. Ellis, R.J., Gamst, A.C., Capparelli, E., Spector, S.A., Hsia, K., Wolfson, T., Abramson, I., Grant, I., McCutchan, J.A. Neurology (2000) [Pubmed]
  6. Immunolocalization of Alzheimer beta-amyloid peptide precursor to cellular membranes in baculovirus expression system. Currie, J.R., Ramakrishna, N., Burrage, T.G., Hwang, M.C., Potempska, A., Miller, D.L., Mehta, P.D., Kim, K.S., Wisniewski, H.M. J. Neurosci. Res. (1991) [Pubmed]
  7. Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes--a model for MHC/disease associations. Zinkernagel, R.M., Pfau, C.J., Hengartner, H., Althage, A. Nature (1985) [Pubmed]
  8. Minimal DNA sequences that control the cell lineage-specific expression of the pro alpha 2(I) collagen promoter in transgenic mice. Niederreither, K., D'Souza, R.N., de Crombrugghe, B. J. Cell Biol. (1992) [Pubmed]
  9. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. Sanes, J.R., Rubenstein, J.L., Nicolas, J.F. EMBO J. (1986) [Pubmed]
  10. Generalized amyloid in a family of Swedish origin. A study of 426 family members in seven generations of a new kinship with neuropathy, nephropathy, and central nervous system involvement. Benson, M.D., Cohen, A.S. Ann. Intern. Med. (1977) [Pubmed]
  11. Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII. Vogler, C., Levy, B., Grubb, J.H., Galvin, N., Tan, Y., Kakkis, E., Pavloff, N., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Molecular basis of invasive Haemophilus influenzae type b disease. Moxon, E.R. J. Infect. Dis. (1992) [Pubmed]
  13. Moxalactam penetration into cerebrospinal fluid in patients with bacterial meningitis. Modai, J., Wolff, M., Lebas, J., Meulemans, A., Manuel, C. Antimicrob. Agents Chemother. (1982) [Pubmed]
  14. Development of cerebrovascular architecture and its relationship to periventricular leukomalacia. Takashima, S., Tanaka, K. Arch. Neurol. (1978) [Pubmed]
  15. Release of immunoreactive substance P in the brain stem upon stimulation of the cranial dura mater with low pH - inhibition by the serotonin (5-HT1) receptor agonist CP 93,129. Messlinger, K., Ebersberger, A., Schaible, H.G. Br. J. Pharmacol. (1998) [Pubmed]
  16. Diffusion of enoxacin into the cerebrospinal fluid in dogs with healthy meninges and with experimental meningitis. Tran Van Tho, n.u.l.l., Armengaud, A., Davet, B. J. Antimicrob. Chemother. (1984) [Pubmed]
  17. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Serafini, B., Rosicarelli, B., Magliozzi, R., Stigliano, E., Aloisi, F. Brain Pathol. (2004) [Pubmed]
  18. Delayed inflammation in rat meninges: implications for migraine pathophysiology. Reuter, U., Bolay, H., Jansen-Olesen, I., Chiarugi, A., Sanchez del Rio, M., Letourneau, R., Theoharides, T.C., Waeber, C., Moskowitz, M.A. Brain (2001) [Pubmed]
  19. Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats. Anthony, D.C., Bolton, S.J., Fearn, S., Perry, V.H. Brain (1997) [Pubmed]
  20. Expression of the myc proto-oncogenes in developing human fetal brain. Hirvonen, H., Mäkelä, T.P., Sandberg, M., Kalimo, H., Vuorio, E., Alitalo, K. Oncogene (1990) [Pubmed]
  21. Pharmacokinetics of trimethoprim and sulfamethoxazole in serum and cerebrospinal fluid of adult patients with normal meninges. Dudley, M.N., Levitz, R.E., Quintiliani, R., Hickingbotham, J.M., Nightingale, C.H. Antimicrob. Agents Chemother. (1984) [Pubmed]
  22. Congenic autoimmune murine models of central nervous system disease in connective tissue disorders. Alexander, E.L., Murphy, E.D., Roths, J.B., Alexander, G.E. Ann. Neurol. (1983) [Pubmed]
  23. Short term treatment with soluble neuroantigen and anti-CD11a (LFA-1) protects rats against autoimmune encephalomyelitis: treatment abrogates autoimmune disease but not autoimmunity. Willenborg, D.O., Staykova, M.A., Miyasaka, M. J. Immunol. (1996) [Pubmed]
  24. Transthyretin Leu12Pro is associated with systemic, neuropathic and leptomeningeal amyloidosis. Brett, M., Persey, M.R., Reilly, M.M., Revesz, T., Booth, D.R., Booth, S.E., Hawkins, P.N., Pepys, M.B., Morgan-Hughes, J.A. Brain (1999) [Pubmed]
  25. Failure of cefamandole in treatment of meningitis due to Haemophilus influenzae type b. Steinberg, E.A., Overturf, G.D., Wilkins, J., Baraff, L.J., Streng, J.M., Leedom, J.M. J. Infect. Dis. (1978) [Pubmed]
  26. Dural "tail" associated with meningiomas on Gd-DTPA-enhanced MR images: characteristics, differential diagnostic value, and possible implications for treatment. Goldsher, D., Litt, A.W., Pinto, R.S., Bannon, K.R., Kricheff, I.I. Radiology. (1990) [Pubmed]
  27. Penetration of aztreonam into cerebrospinal fluid of patients with and without inflamed meninges. Duma, R.J., Berry, A.J., Smith, S.M., Baggett, J.W., Swabb, E.A., Platt, T.B. Antimicrob. Agents Chemother. (1984) [Pubmed]
  28. Intrathecal penetration of N-formimidoyl thienamycin in normal rabbits: potentiation by coadministration of renal dipeptidase enzyme inhibitor. Chow, A.W., Finlay, K.R., Stiver, H.G., Carlson, C.L. Antimicrob. Agents Chemother. (1983) [Pubmed]
  29. Brain histaminergic system in mast cell-deficient (Ws/Ws) rats: histamine content, histidine decarboxylase activity, and effects of (S) alpha-fluoromethylhistidine. Sugimoto, K., Maeyama, K., Alam, K., Sakurai, E., Onoue, H., Kasugai, T., Kitamura, Y., Watanabe, T. J. Neurochem. (1995) [Pubmed]
  30. Penetration of pefloxacin into cerebrospinal fluid of patients with meningitis. Wolff, M., Regnier, B., Daldoss, C., Nkam, M., Vachon, F. Antimicrob. Agents Chemother. (1984) [Pubmed]
  31. Cytokine enhancement of complement-dependent phagocytosis by macrophages: synergy of tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor for phagocytosis of Cryptococcus neoformans. Collins, H.L., Bancroft, G.J. Eur. J. Immunol. (1992) [Pubmed]
  32. Intraventricular administration of hepatocyte growth factor treats mouse communicating hydrocephalus induced by transforming growth factor beta1. Tada, T., Zhan, H., Tanaka, Y., Hongo, K., Matsumoto, K., Nakamura, T. Neurobiol. Dis. (2006) [Pubmed]
  33. Neuronal migration. Lambert de Rouvroit, C., Goffinet, A.M. Mech. Dev. (2001) [Pubmed]
  34. Antibody to myelin-associated glycoprotein reacts with plasma cells in mice. Dal Canto, M.C., Barbano, R.L. J. Neuroimmunol. (1986) [Pubmed]
  35. Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice. Hitzler, J.K., Soares, H.D., Drolet, D.W., Inaba, T., O'Connel, S., MG Rosenfeld, n.u.l.l., Morgan, J.I., Look, A.T. Brain Res. (1999) [Pubmed]
  36. Vascular endothelial growth factor in CSF: a biological marker for carcinomatous meningitis. Stockhammer, G., Poewe, W., Burgstaller, S., Deisenhammer, F., Muigg, A., Kiechl, S., Schmutzhard, E., Maier, H., Felber, S., Schumacher, P., Gunsilius, E., Gastl, G. Neurology (2000) [Pubmed]
  37. Carboxy terminal sequence and synthesis of rat kidney laminin gamma 1 chain. Vanden Heuvel, G.B., Leardkamolkarn, V., St John, P.L., Abrahamson, D.R. Kidney Int. (1996) [Pubmed]
  38. Experimental pneumococcal meningitis in mice: a model of intranasal infection. Zwijnenburg, P.J., van der Poll, T., Florquin, S., van Deventer, S.J., Roord, J.J., van Furth, A.M. J. Infect. Dis. (2001) [Pubmed]
  39. Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brain. Morse, D.C., Stein, A.P., Thomas, P.E., Lowndes, H.E. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
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