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Gene Review:

Kr-h1 - Kruppel homolog 1

Drosophila melanogaster

Synonyms: 44/11, CG18783, CG45074, CG9167, Dmel\CG45074, ...

Pecasse, F. et al., Grozinger, C.M. et al., Beck, Y. et al.

Grozinger, Sharabash, Whitfield, Robinson,

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High impact information on Kr-h1

We also report here on an ortholog of the Drosophila transcription factor kruppel homolog 1 that was strongly regulated by QMP, especially in the mushroom bodies of the bee brain [1].
At metamorphosis, the Krüppel-homolog (Kr-h) gene, coding for a zinc finger protein, is required during the prepupal ecdysone response [2].
Our studies on the corresponding gene, named Krüppel-homolog (Kr-h), add to a growing body of evidence that specific isoforms of a number of key genes are implicated in both embryogenesis and metamorphosis [3].

References

Pheromone-mediated gene expression in the honey bee brain. Grozinger, C.M., Sharabash, N.M., Whitfield, C.W., Robinson, G.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Krüppel-homolog is essential for the coordination of regulatory gene hierarchies in early Drosophila development. Beck, Y., Pecasse, F., Richards, G. Dev. Biol. (2004) [Pubmed]
Krüppel-homolog, a stage-specific modulator of the prepupal ecdysone response, is essential for Drosophila metamorphosis. Pecasse, F., Beck, Y., Ruiz, C., Richards, G. Dev. Biol. (2000) [Pubmed]

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