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Gene Review:

PB301263.00.0 - glutathione S-transferase

Plasmodium berghei ANKA

Possani, L.D. et al., Chander, R. et al., Platel, D.F. et al., Srivastava, P. et al.

Platel, Mangou, Tribouley-Duret, Srivastava, Puri, Kamboj, Pandey,

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High impact information on PB301263.00.0

Using NK65-derived lines displaying increasing resistance levels, we observed an inverse relationship between the hemozoin content, and the glutathione (GSH) and glutathione S-transferase (GST) levels [1].
Complete inhibition of chloroquine-sensitive and resistant P. berghei glutathione-S-transferase activities was observed at 2.5 and 5. micrometer concentration of hemin, respectively [2].
The depletion of reduced glutathione level and inhibition of glutathione-S-transferase, glutathione reductase and glutathione peroxidase activities due to P. berghei infection were markedly recovered by picroliv [3].

Analytical, diagnostic and therapeutic context of PB301263.00.0

A synthetic Shiva-3 gene was constructed by recursive polymerase-chain reaction (PCR) methodology and expressed using the vector pGEX2T as a hybrid protein between the glutathione-S-transferase at the N-terminal and Shiva-3 in the C-terminal part of the hybrid [4].

References

Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei. Platel, D.F., Mangou, F., Tribouley-Duret, J. Mol. Biochem. Parasitol. (1999) [Pubmed]
Glutathione-S-transferase activity in malarial parasites. Srivastava, P., Puri, S.K., Kamboj, K.K., Pandey, V.C. Trop. Med. Int. Health (1999) [Pubmed]
Effect of picroliv on glutathione metabolism in liver and brain of Mastomys natalensis infected with Plasmodium berghei. Chander, R., Kapoor, N.K., Dhawan, B.N. Indian J. Exp. Biol. (1992) [Pubmed]
From noxiustoxin to Shiva-3, a peptide toxic to the sporogonic development of Plasmodium berghei. Possani, L.D., Zurita, M., Delepierre, M., Hernández, F.H., Rodríguez, M.H. Toxicon (1998) [Pubmed]

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