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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IFIT3  -  interferon-induced protein with...

Homo sapiens

Synonyms: CIG-49, CIG49, GARG-49, IFI-60K, IFI60, ...
 
 
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High impact information on IFIT3

  • Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes [1].
  • ATRA treatment induces the transcriptional expression of RIG-G relatively late (12-24 hr) in a protein synthesis-dependent manner, whereas IFN-alpha induces its expression early (30 min to 3 hr) [1].
  • The tRA-induced expression of RIG-G, Bfl-1/A1, and p21(waf1) and, to a lesser extent, of CCAAT/enhancer binding protein-epsilon (C/EBPepsilon) are also enhanced by such combined treatments [2].
  • RESULTS: IdeR binds to the predicted binding site, which overlaps with the irg1 promoter. irg1 and irg2 expression was decreased by iron in M. tuberculosis and in wild type M. smegmatis, but not in a M. smegmatis ideR mutant [3].
  • IFIT3 has sense Alu elements in its 3'UTR region, making it susceptible to the regulation of other protein-coding or non-coding RNAs with antisense Alu elements [4].
 

Biological context of IFIT3

References

  1. Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes. Yu, M., Tong, J.H., Mao, M., Kan, L.X., Liu, M.M., Sun, Y.W., Fu, G., Jing, Y.K., Yu, L., Lepaslier, D., Lanotte, M., Wang, Z.Y., Chen, Z., Waxman, S., Wang, Y.X., Tan, J.Z., Chen, S.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. Jing, Y., Xia, L., Waxman, S. Blood (2002) [Pubmed]
  3. Identification and characterization of two divergently transcribed iron regulated genes in Mycobacterium tuberculosis. Rodriguez, G.M., Gold, B., Gomez, M., Dussurget, O., Smith, I. Tuber. Lung Dis. (1999) [Pubmed]
  4. A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. Liang, K.H., Yeh, C.T. BMC. Genomics. (2013) [Pubmed]
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