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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IFNA4  -  interferon, alpha 4

Homo sapiens

Synonyms: IFN-alpha-4, IFN-alpha4a, INFA4, Interferon alpha-4, Interferon alpha-4B, ...
 
 
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High impact information on IFNA4

  • The murine IFNA4 promoter, which can be induced by IRF-1 or viral infection, is not induced by IRF-3 [1].
  • However, the fusion protein generated from the IRF-3 binding domain and the RelA(p65) activation domain effectively activates both IFNA4 and IFNB promoters [2].
  • Maximal activation of murine infection-A4 (IFNA4) gene transcription following viral infection requires the presence of four cooperating DNA sequences (denoted A to D), which make up the virus responsive element VRE-A4 [3].
 

Other interactions of IFNA4

  • We also show that the C module is critical for both IRF-3-mediated and virus-induced transcription of the murine IFNA4 gene [3].

References

  1. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Au, W.C., Moore, P.A., Lowther, W., Juang, Y.T., Pitha, P.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Regulation of type I interferon gene expression by interferon regulatory factor-3. Schafer, S.L., Lin, R., Moore, P.A., Hiscott, J., Pitha, P.M. J. Biol. Chem. (1998) [Pubmed]
  3. The virus-induced factor VIF differentially recognizes the virus-responsive modules of the mouse IFNA4 gene promoter. Morin, P., Génin, P., Doly, J., Civas, A. J. Interferon Cytokine Res. (2002) [Pubmed]
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