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Gene Review

Ifna1  -  interferon-alpha 1

Rattus norvegicus

Synonyms: Interferon alpha-1
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Disease relevance of Ifna1


Psychiatry related information on Ifna1


High impact information on Ifna1


Chemical compound and disease context of Ifna1


Biological context of Ifna1

  • Gel mobility shift of the interferon gamma activation site/interferon alpha-stimulating response element was observed immediately after the aortic banding, whereas the band of sis-inducing element was shifted in the late stage at 60 minutes [17].
  • Interferon alpha-induced apoptosis on rat preneoplastic liver is mediated by hepatocytic transforming growth factor beta(1) [18].
  • In contrast, interferon-alpha and dexamethasone did not alter C1-esterase inhibitor gene expression [19].
  • The decreased cell proliferation caused by IFN-alpha-induced IL-1beta may be responsible, at least in part, for IFN-alpha-induced depression.Neuropsychopharmacology (2006) 31, 2619-2626. doi:10.1038/sj.npp.1301137; published online 5 July 2006 [20].
  • Immediately after the administration of IFN-alpha for 1 week, a decrease in the number of 5-bromo-deoxyuridine-labeled proliferating cells was observed in the DG; however, no effect was detected on the expression of mature neuronal phenotype in the newly formed cells 3 weeks later [20].

Anatomical context of Ifna1


Associations of Ifna1 with chemical compounds


Regulatory relationships of Ifna1


Other interactions of Ifna1


Analytical, diagnostic and therapeutic context of Ifna1


  1. Structure and expression in Escherichia coli of a cloned rat interferon-alpha gene. Dijkema, R., Pouwels, P., de Reus, A., Schellekens, H. Nucleic Acids Res. (1984) [Pubmed]
  2. Protein kinase regulates tumor necrosis factor mRNA stability in virus-stimulated astrocytes. Lieberman, A.P., Pitha, P.M., Shin, M.L. J. Exp. Med. (1990) [Pubmed]
  3. Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins. Arnheiter, H., Haller, O. EMBO J. (1988) [Pubmed]
  4. Reduced synthesis of pp60src and expression of the transformation-related phenotype in interferon-treated Rous sarcoma virus-transformed rat cells. Lin, S.L., Garber, E.A., Wang, E., Caliguiri, L.A., Schellekens, H., Goldberg, A.R., Tamm, I. Mol. Cell. Biol. (1983) [Pubmed]
  5. Analgesic effect of interferon-alpha via mu opioid receptor in the rat. Jiang, C.L., Son, L.X., Lu, C.L., You, Z.D., Wang, Y.X., Sun, L.Y., Cui, R.Y., Liu, X.Y. Neurochem. Int. (2000) [Pubmed]
  6. Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier. Kitagami, T., Yamada, K., Miura, H., Hashimoto, R., Nabeshima, T., Ohta, T. Brain Res. (2003) [Pubmed]
  7. Effect of interferon-alpha on tyrosine hydroxylase and catecholamine levels in the brain of rats. Kumai, T., Tateishi, T., Tanaka, M., Watanabe, M., Shimizu, H., Kobayashi, S. Life Sci. (2000) [Pubmed]
  8. Islet expression of interferon-alpha precedes diabetes in both the BB rat and streptozotocin-treated mice. Huang, X., Hultgren, B., Dybdal, N., Stewart, T.A. Immunity (1994) [Pubmed]
  9. Spontaneous transformation of rat ovarian surface epithelial cells: association with cytogenetic changes and implications of repeated ovulation in the etiology of ovarian cancer. Godwin, A.K., Testa, J.R., Handel, L.M., Liu, Z., Vanderveer, L.A., Tracey, P.A., Hamilton, T.C. J. Natl. Cancer Inst. (1992) [Pubmed]
  10. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. Dupont, G.P., Huecksteadt, T.P., Marshall, B.C., Ryan, U.S., Michael, J.R., Hoidal, J.R. J. Clin. Invest. (1992) [Pubmed]
  11. Homozygous deletions on the short arm of chromosome 9 in ovarian adenocarcinoma cell lines and loss of heterozygosity in sporadic tumors. Chenevix-Trench, G., Kerr, J., Friedlander, M., Hurst, T., Sanderson, B., Coglan, M., Ward, B., Leary, J., Khoo, S.K. Am. J. Hum. Genet. (1994) [Pubmed]
  12. Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes. Ilyin, G.P., Langouët, S., Rissel, M., Delcros, J.G., Guillouzo, A., Guguen-Guillouzo, C. Hepatology (1998) [Pubmed]
  13. Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model. Suzuki, K., Aoki, K., Ohnami, S., Yoshida, K., Kazui, T., Kato, N., Inoue, K., Kohara, M., Yoshida, T. Gene Ther. (2003) [Pubmed]
  14. In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha. Wang, Z.H., Zagzag, D., Zeng, B., Kolodny, E.H. J. Neuropathol. Exp. Neurol. (1999) [Pubmed]
  15. Effects of long-term administration of interferon alpha in two models of liver fibrosis in rats. Fort, J., Pilette, C., Veal, N., Oberti, F., Gallois, Y., Douay, O., Rosenbaum, J., Calès, P. J. Hepatol. (1998) [Pubmed]
  16. The effects of acetylsalicylic acid, interferon-alpha, and vitamin E on prevention of parenteral nutrition-associated cholestasis: an experimental study. Demircan, M., Ugaralp, S., Mutus, M., Gurer, E.I., Atik, E., Turhan, F., Gursoy, M.H. J. Pediatr. Gastroenterol. Nutr. (1999) [Pubmed]
  17. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Pan, J., Fukuda, K., Kodama, H., Makino, S., Takahashi, T., Sano, M., Hori, S., Ogawa, S. Circ. Res. (1997) [Pubmed]
  18. Interferon alpha-induced apoptosis on rat preneoplastic liver is mediated by hepatocytic transforming growth factor beta(1). de Luján Alvarez, M., Ronco, M.T., Ochoa, J.E., Monti, J.A., Carnovale, C.E., Pisani, G.B., Lugano, M.C., Carrillo, M.C. Hepatology (2004) [Pubmed]
  19. Fat-storing cells of the rat liver synthesize and secrete C1-esterase inhibitor; modulation by cytokines. Schwögler, S., Odenthal, M., Knittel, T., Meyer zum Büschenfelde, K.H., Ramadori, G. Hepatology (1992) [Pubmed]
  20. Suppression of Cell Proliferation by Interferon-Alpha through Interleukin-1 Production in Adult Rat Dentate Gyrus. Kaneko, N., Kudo, K., Mabuchi, T., Takemoto, K., Fujimaki, K., Wati, H., Iguchi, H., Tezuka, H., Kanba, S. Neuropsychopharmacology (2006) [Pubmed]
  21. Prednisolone, platelet-activating factor receptor antagonist, or superoxide dismutase reduced leukocyte entrapment induced by interferon alpha in retinal microcirculation. Nishiwaki, H., Ogura, Y., Miyamoto, K., Hiroshiba, N., Hamada, M., Honda, Y. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  22. Hypothalamic modulation of splenic natural killer cell activity in rats. Katafuchi, T., Ichijo, T., Take, S., Hori, T. J. Physiol. (Lond.) (1993) [Pubmed]
  23. Roles of sympathetic nervous system in the suppression of cytotoxicity of splenic natural killer cells in the rat. Katafuchi, T., Take, S., Hori, T. J. Physiol. (Lond.) (1993) [Pubmed]
  24. Interferon-alpha and -gamma expression in the rat testis. Dejucq, N., Dugast, I., Ruffault, A., van der Meide, P.H., Jégou, B. Endocrinology (1995) [Pubmed]
  25. Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Ellerman, K.E., Like, A.A. Diabetologia (2000) [Pubmed]
  26. Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo. Terao, M., Cazzaniga, G., Ghezzi, P., Bianchi, M., Falciani, F., Perani, P., Garattini, E. Biochem. J. (1992) [Pubmed]
  27. Double-stranded ribonucleic acid decreases c6 rat glioma cell proliferation in part by activating protein kinase R and decreasing insulin-like growth factor I levels. Chacko, M.S., Ma, X., Adamo, M.L. Endocrinology (2002) [Pubmed]
  28. Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats. Olsen, N.J., Nicholson, W.E., DeBold, C.R., Orth, D.N. Endocrinology (1992) [Pubmed]
  29. Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase. Stewart, V.C., Giovannoni, G., Land, J.M., McDonald, W.I., Clark, J.B., Heales, S.J. J. Neurochem. (1997) [Pubmed]
  30. Arginine vasopressin release by acetylcholine or norepinephrine: region-specific and cytokine-specific regulation. Raber, J., Bloom, F.E. Neuroscience (1996) [Pubmed]
  31. Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation. Shen, H., Zhang, M., Minuk, G.Y., Gong, Y. BMC Cell Biol. (2002) [Pubmed]
  32. Inhibition by interferon alpha-2b of rat liver regeneration: effect on ornithine decarboxylase and total protein synthesis. Favre, C., Carnovale, C.E., Monti, J.A., Carrillo, M.C. Biochem. Pharmacol. (2001) [Pubmed]
  33. PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia. Lee, J.H., Joe, E.H., Jou, I. Neuroreport (2005) [Pubmed]
  34. Cytokines inhibit proliferation and insulin secretion by clonal rat insulinoma cells (RINm5F) non-synergistically and in a pertussis toxin-insensitive manner. Sjöholm, A. Immunol. Lett. (1991) [Pubmed]
  35. Cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC): response to genistein and pyrrolidine dithiocarbamate. Li, W., Xia, J., Sun, G.Y. J. Interferon Cytokine Res. (1999) [Pubmed]
  36. Neuropeptide Y counteracts interferon-alpha-induced anorexia. Turrin, N.P., Flynn, M.C., Plata-Salamán, C.R. Neuroimmunomodulation (1999) [Pubmed]
  37. The effects of 5-fluorouracil and interferon-alpha on early healing of experimental intestinal anastomoses. de Waard, J.W., Wobbes, T., de Man, B.M., van der Linden, C.J., Hendriks, T. Br. J. Cancer (1996) [Pubmed]
  38. Interferon-alpha stimulates the hypothalamic-pituitary-adrenal axis in vivo and in vitro. Gisslinger, H., Svoboda, T., Clodi, M., Gilly, B., Ludwig, H., Havelec, L., Luger, A. Neuroendocrinology (1993) [Pubmed]
  39. The effects of interferon-alpha/beta in a model of rat heart transplantation. Slater, A.D., Klein, J.B., Sonnenfeld, G., Ogden, L.L., Gray, L.A. J. Heart Lung Transplant. (1992) [Pubmed]
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