Gene Review:
IRF1 - interferon regulatory factor 1
Homo sapiens
Synonyms:
IRF-1, Interferon regulatory factor 1, MAR
- Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes. Kumar, A., Kumar, A., Michael, P., Brabant, D., Parissenti, A.M., Ramana, C.V., Xu, X., Parrillo, J.E. J. Biol. Chem. (2005)
- Alterations in IRF1/IRF2 expression in acute myelogenous leukemia. Preisler, H.D., Perambakam, S., Li, B., Hsu, W.T., Venugopal, P., Creech, S., Sivaraman, S., Tanaka, N. Am. J. Hematol. (2001)
- Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells. Matikainen, S., Ronni, T., Hurme, M., Pine, R., Julkunen, I. Blood (1996)
- Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors. Lubyova, B., Pitha, P.M. J. Virol. (2000)
- A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. Chang, T.L., Mosoian, A., Pine, R., Klotman, M.E., Moore, J.P. J. Virol. (2002)
- Regulation of hepatitis C virus replication by interferon regulatory factor 1. Kanazawa, N., Kurosaki, M., Sakamoto, N., Enomoto, N., Itsui, Y., Yamashiro, T., Tanabe, Y., Maekawa, S., Nakagawa, M., Chen, C.H., Kakinuma, S., Oshima, S., Nakamura, T., Kato, T., Wakita, T., Watanabe, M. J. Virol. (2004)
- The role of interferon regulatory factors in the interferon system and cell growth control. Harada, H., Taniguchi, T., Tanaka, N. Biochimie (1998)
- Variations in the slope of the psychometric acuity function with acuity threshold and scale. Horner, D.G., Paul, A.D., Katz, B., Bedell, H.E. American journal of optometry and physiological optics. (1985)
- IRF family of transcription factors as regulators of host defense. Taniguchi, T., Ogasawara, K., Takaoka, A., Tanaka, N. Annu. Rev. Immunol. (2001)
- A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Dickinson, L.A., Joh, T., Kohwi, Y., Kohwi-Shigematsu, T. Cell (1992)
- A matrix/scaffold attachment region binding protein: identification, purification, and mode of binding. von Kries, J.P., Buhrmester, H., Strätling, W.H. Cell (1991)
- Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Escalante, C.R., Yie, J., Thanos, D., Aggarwal, A.K. Nature (1998)
- Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway. Percario, Z.A., Giandomenico, V., Fiorucci, G., Chiantore, M.V., Vannucchi, S., Hiscott, J., Affabris, E., Romeo, G. Cell Growth Differ. (1999)
- IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. Sancéau, J., Hiscott, J., Delattre, O., Wietzerbin, J. Oncogene (2000)
- Interferon regulatory factor-1 and -2 expression in human melanoma specimens. Lowney, J.K., Boucher, L.D., Swanson, P.E., Doherty, G.M. Ann. Surg. Oncol. (1999)
- Posttranscriptional inhibition of gene expression by Mycobacterium tuberculosis offsets transcriptional synergism with IFN-gamma and posttranscriptional up-regulation by IFN-gamma. Qiao, Y., Prabhakar, S., Canova, A., Hoshino, Y., Weiden, M., Pine, R. J. Immunol. (2004)
- Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. Liu, L., Paul, A., MacKenzie, C.J., Bryant, C., Graham, A., Plevin, R. Br. J. Pharmacol. (2001)
- Identification of a novel transcriptional regulatory element common to the p53 and interferon regulatory factor 1 genes. Lallemand, C., Bayat-Sarmadi, M., Blanchard, B., Tovey, M.G. J. Biol. Chem. (1997)
- Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B. Sancéau, J., Boyd, D.D., Seiki, M., Bauvois, B. J. Biol. Chem. (2002)
- Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. Nakao, F., Ihara, K., Kusuhara, K., Sasaki, Y., Kinukawa, N., Takabayashi, A., Nishima, S., Hara, T. J. Allergy Clin. Immunol. (2001)
- Expression of interferon regulatory factor (IRF) genes and response to interferon-alpha in chronic myeloid leukaemia. Hochhaus, A., Yan, X.H., Willer, A., Hehlmann, R., Gordon, M.Y., Goldman, J.M., Melo, J.V. Leukemia (1997)
- MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells. Horiuchi, M., Itoh, A., Pleasure, D., Itoh, T. J. Biol. Chem. (2006)
- Human cancer cell lines express a negative transcriptional regulator of the interferon regulatory factor family of DNA binding proteins. Petricoin, E., David, M., Fang, H., Grimley, P., Larner, A.C., Vande Pol, S. Mol. Cell. Biol. (1994)
- Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Oshima, S., Nakamura, T., Namiki, S., Okada, E., Tsuchiya, K., Okamoto, R., Yamazaki, M., Yokota, T., Aida, M., Yamaguchi, Y., Kanai, T., Handa, H., Watanabe, M. Mol. Cell. Biol. (2004)
- Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases. Liu, T., Castro, S., Brasier, A.R., Jamaluddin, M., Garofalo, R.P., Casola, A. J. Biol. Chem. (2004)
- Interferon regulatory factor-1 regulates reconstituted extracellular matrix (rECM)-mediated apoptosis in human mammary epithelial cells. Bowie, M.L., Troch, M.M., Delrow, J., Dietze, E.C., Bean, G.R., Ibarra, C., Pandiyan, G., Seewaldt, V.L. Oncogene (2007)
- Interaction between the interferon signaling pathway and the human glucocorticoid receptor gene 1A promoter. Nunez, B.S., Geng, C.D., Pedersen, K.B., Millro-Macklin, C.D., Vedeckis, W.V. Endocrinology (2005)
- Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Bovolenta, C., Driggers, P.H., Marks, M.S., Medin, J.A., Politis, A.D., Vogel, S.N., Levy, D.E., Sakaguchi, K., Appella, E., Coligan, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Association of 2',5'-oligoadenylate synthetase with the prolactin (PRL) receptor: alteration in PRL-inducible stat1 (signal transducer and activator of transcription 1) signaling to the IRF-1 (interferon-regulatory factor 1) promoter. McAveney, K.M., Book, M.L., Ling, P., Chebath, J., Yu-Lee, L. Mol. Endocrinol. (2000)
- Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA. Harroch, S., Revel, M., Chebath, J. EMBO J. (1994)
- Growth arrest of epithelial cells during measles virus infection is caused by upregulation of interferon regulatory factor 1. Yokota, S., Okabayashi, T., Yokosawa, N., Fujii, N. J. Virol. (2004)
- Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. Harada, H., Takahashi, E., Itoh, S., Harada, K., Hori, T.A., Taniguchi, T. Mol. Cell. Biol. (1994)
- Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells. Stang, M.T., Armstrong, M.J., Watson, G.A., Sung, K.Y., Liu, Y., Ren, B., Yim, J.H. Oncogene (2007)
- Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta. Piskurich, J.F., Linhoff, M.W., Wang, Y., Ting, J.P. Mol. Cell. Biol. (1999)
- Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. Lehtonen, A., Matikainen, S., Julkunen, I. J. Immunol. (1997)
- Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. Barnes, B.J., Moore, P.A., Pitha, P.M. J. Biol. Chem. (2001)
- Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patients. Condos, R., Raju, B., Canova, A., Zhao, B.Y., Weiden, M., Rom, W.N., Pine, R. Infect. Immun. (2003)
- Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease. Salvati, V.M., MacDonald, T.T., del Vecchio Blanco, G., Mazzarella, G., Monteleone, I., Vavassori, P., Auricchio, S., Pallone, F., Troncone, R., Monteleone, G. Pediatr. Res. (2003)
- Peptide YY Reverses TNF-alpha Induced Transcription Factor Binding of Interferon Regulatory Factor-1 and p53 in Pancreatic Acinar Cells. Rizvi, I.A., Robinson, K., McFadden, D.W., Riggs, D.R., Jackson, B.J., Vona-Davis, L. J. Surg. Res. (2006)