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Gene Review

Ifna15  -  interferon alpha 15

Mus musculus

Synonyms: Gm12597, Ifnaa, MuIFN-alpha-A, OTTMUSG00000007655
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Disease relevance of OTTMUSG00000007655


High impact information on OTTMUSG00000007655

  • In the accompanying paper we have shown that the accumulation of mRNA after viral induction is due to activation of transcription, rather than to reduction of turnover, and that the regulation of the alpha-interferon (IFN-alpha) gene is mediated by a segment of 5'-flanking region of not more than 700 base pairs (bp) [6].
  • The presence of human chromosome 9 in a hybrid correlated with the presence of a family of alpha interferon genes [7].
  • Interestingly, alpha-interferon treatment was found to slowly revert the abnormal motility phenotype of BCR/ABL-transformed cells towards normal [8].
  • This association did not play a role in regulating transgene expression, but PML protein was necessary for the inhibition of transgene expression with alpha interferon (IFN-alpha) [9].
  • The rapid induction of alpha interferon (IFN-alpha) and IFN-beta expression plays a critical role in the innate immune response against viral infection [10].

Chemical compound and disease context of OTTMUSG00000007655


Biological context of OTTMUSG00000007655


Anatomical context of OTTMUSG00000007655


Associations of OTTMUSG00000007655 with chemical compounds


Other interactions of OTTMUSG00000007655


Analytical, diagnostic and therapeutic context of OTTMUSG00000007655


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  2. Leukemic burden in subpopulations of CD34+ cells isolated from the mobilized peripheral blood of alpha-interferon-resistant or -intolerant patients with chronic myeloid leukemia. Van den Berg, D., Wessman, M., Murray, L., Tong, J., Chen, B., Chen, S., Simonetti, D., King, J., Yamasaki, G., DiGiusto, R., Gearing, D., Reading, C. Blood (1996) [Pubmed]
  3. Modulation of the expression of major histocompatibility antigens on splenic hairy cells--differential effect upon in vitro treatment with alpha-2b-interferon, gamma-interferon, and interleukin-2. Gressler, V.H., Weinkauff, R.E., Franklin, W.A., Golomb, H.M. Blood (1988) [Pubmed]
  4. Synergistic antitumor effects of combination immunotherapy with recombinant interleukin-2 and a recombinant hybrid alpha-interferon in the treatment of established murine hepatic metastases. Cameron, R.B., McIntosh, J.K., Rosenberg, S.A. Cancer Res. (1988) [Pubmed]
  5. Enhanced TAG-72 expression and tumor uptake of radiolabeled monoclonal antibody CC49 in metastatic breast cancer patients following alpha-interferon treatment. Murray, J.L., Macey, D.J., Grant, E.J., Rosenblum, M.G., Kasi, L.P., Zhang, H.Z., Katz, R.L., Riger, P.T., LeBherz, D., Bhadkamkar, V. Cancer Res. (1995) [Pubmed]
  6. Not more than 117 base pairs of 5'-flanking sequence are required for inducible expression of a human IFN-alpha gene. Ragg, H., Weissmann, C. Nature (1983) [Pubmed]
  7. Chromosomal location of a human alpha interferon gene family. Slate, D.L., D'Eustachio, P., Pravtcheva, D., Cunningham, A.C., Nagata, S., Weissmann, C., Ruddle, F.H. J. Exp. Med. (1982) [Pubmed]
  8. BCR/ABL induces multiple abnormalities of cytoskeletal function. Salgia, R., Li, J.L., Ewaniuk, D.S., Pear, W., Pisick, E., Burky, S.A., Ernst, T., Sattler, M., Chen, L.B., Griffin, J.D. J. Clin. Invest. (1997) [Pubmed]
  9. Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA. Bishop, C.L., Ramalho, M., Nadkarni, N., May Kong, W., Higgins, C.F., Krauzewicz, N. Mol. Cell. Biol. (2006) [Pubmed]
  10. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Qing, J., Liu, C., Choy, L., Wu, R.Y., Pagano, J.S., Derynck, R. Mol. Cell. Biol. (2004) [Pubmed]
  11. Antiproliferative and antitumor effects of alpha-interferon in renal cell carcinomas: correlation with the expression of a kidney-associated differentiation glycoprotein. Nanus, D.M., Pfeffer, L.M., Bander, N.H., Bahri, S., Albino, A.P. Cancer Res. (1990) [Pubmed]
  12. Inhibition of intrahepatic hepatitis B virus replication by antiviral drugs in a novel transgenic mouse model. Nagahata, T., Araki, K., Yamamura, K., Matsubara, K. Antimicrob. Agents Chemother. (1992) [Pubmed]
  13. Anti-EpCAM monoclonal antibody (MAb17-1A) based treatment combined with alpha-interferon, 5-fluorouracil and granulocyte-macrophage colony-stimulating factor in patients with metastatic colorectal carcinoma. Liljefors, M., Ragnhammar, P., Nilsson, B., Ullenhag, G., Mellstedt, H., Frödin, J.E. Int. J. Oncol. (2004) [Pubmed]
  14. Intracellular Ca2+ and cytotoxicity. Lynn, W.S., Mathews, D., Cloyd, M., Wallwork, J.C., Thompson, A., Sachs, C. Arch. Environ. Health (1989) [Pubmed]
  15. Enhanced accumulation of ribavirin and its metabolites in liver versus erythrocytes in mice administered with the liver targeted drug. Di Stefano, G., Bignamini, A., Busi, C., Colonna, F.P., Fiume, L. Italian journal of gastroenterology and hepatology. (1997) [Pubmed]
  16. Structure of a murine alpha interferon pseudogene with a repetitive R-type sequence in the 3' flanking region. Le Roscouet, D., Vodjdani, G., Lemaigre-Dubreuil, Y., Tovey, M.G., Latta, M., Doly, J. Mol. Cell. Biol. (1985) [Pubmed]
  17. Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene. Baldwin, A.S., Sharp, P.A. Mol. Cell. Biol. (1987) [Pubmed]
  18. Malignant monoblasts can function as effector cells in natural killer cell and antibody-dependent cellular cytotoxicity assays. Hokland, P., Hokland, M., Ellegaard, J. Blood (1981) [Pubmed]
  19. Treatment of hairy cell leukemia with recombinant alpha interferon: II. In vivo down-regulation of alpha interferon receptors on tumor cells. Billard, C., Sigaux, F., Castaigne, S., Valensi, F., Flandrin, G., Degos, L., Falcoff, E., Aguet, M. Blood (1986) [Pubmed]
  20. Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells. Chen, K., Huang, J., Zhang, C., Huang, S., Nunnari, G., Wang, F.X., Tong, X., Gao, L., Nikisher, K., Zhang, H. J. Virol. (2006) [Pubmed]
  21. Interactive effects of alpha-interferon A/D and interleukin 2 on murine lymphokine-activated killer activity: analysis at the effector and precursor level. Chikkala, N.F., Lewis, I., Ulchaker, J., Stanley, J., Tubbs, R., Finke, J.H. Cancer Res. (1990) [Pubmed]
  22. Herpes simplex virus-induced suppression of macrophage-mediated tumoricidal activity in murine macrophages. Koff, W.C., Dunegan, M.A., Chakrabarty, M.K., Hampar, B., Showalter, S.D. Cancer Res. (1987) [Pubmed]
  23. Enhanced in vivo therapeutic response to interferon in mice with an in vitro interferon-resistant B-cell lymphoma. Reid, T.R., Race, E.R., Wolff, B.H., Friedman, R.M., Merigan, T.C., Basham, T.Y. Cancer Res. (1989) [Pubmed]
  24. Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine. Tiwari, R.K., Kusari, J., Kumar, R., Sen, G.C. Mol. Cell. Biol. (1988) [Pubmed]
  25. Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy. Kamm, V.J., Rietjens, I.M., Vervoort, J., Heerschap, A., Rosenbusch, G., Hofs, H.P., Wagener, D.J. Cancer Res. (1994) [Pubmed]
  26. Synergistic potentiation of in vivo antitumor activity of anti-human T-leukemia immunotoxins by recombinant alpha-interferon and daunorubicin. Yokota, S., Hara, H., Luo, Y., Seon, B.K. Cancer Res. (1990) [Pubmed]
  27. Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents. Mohammad, R.M., al-Katib, A., Pettit, G.R., Sensenbrenner, L.L. Cancer Res. (1994) [Pubmed]
  28. Erythroblast transformation by the friend spleen focus-forming virus is associated with a block in erythropoietin-induced STAT1 phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-1. Nishigaki, K., Hanson, C., Ohashi, T., Spadaccini, A., Ruscetti, S. J. Virol. (2006) [Pubmed]
  29. Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions. Lu, M.M., Chen, F., Gitler, A., Li, J., Jin, F., Ma, X.K., Epstein, J.A. Dev. Genes Evol. (2000) [Pubmed]
  30. Combination cytokine immunotherapy with tumor necrosis factor alpha, interleukin 2, and alpha-interferon and its synergistic antitumor effects in mice. McIntosh, J.K., Mulé, J.J., Krosnick, J.A., Rosenberg, S.A. Cancer Res. (1989) [Pubmed]
  31. Enhancement of metastatic potential by gamma-interferon. Kelly, S.A., Gschmeissner, S., East, N., Balkwill, F.R. Cancer Res. (1991) [Pubmed]
  32. Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1. Kawamoto, S., Oritani, K., Asada, H., Takahashi, I., Ishikawa, J., Yoshida, H., Yamada, M., Ishida, N., Ujiie, H., Masaie, H., Tomiyama, Y., Matsuzawa, Y. J. Virol. (2003) [Pubmed]
  33. Enhanced therapeutic efficacy against an ovarian tumor xenograft of immunotoxins used in conjunction with recombinant alpha-interferon. Pearson, J.W., Hedrick, E., Fogler, W.E., Bull, R.L., Ferris, D.K., Riggs, C.W., Wiltrout, R.H., Sivam, G., Morgan, A.C., Groves, E. Cancer Res. (1990) [Pubmed]
  34. Regulated and liver-specific tamarin alpha interferon gene delivery by a helper-dependent adenoviral vector. Aurisicchio, L., De Tomassi, A., La Monica, N., Ciliberto, G., Traboni, C., Palombo, F. J. Virol. (2005) [Pubmed]
  35. West Nile virus inhibits the signal transduction pathway of alpha interferon. Guo, J.T., Hayashi, J., Seeger, C. J. Virol. (2005) [Pubmed]
  36. Interferon production by leukocytes infiltrating the lungs of mice during primary influenza virus infection. Wyde, P.R., Wilson, M.R., Cate, T.R. Infect. Immun. (1982) [Pubmed]
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