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Gene Review:

Sir2 - CG5216 gene product from transcript CG5216-RA

Drosophila melanogaster

Synonyms: BEST:LD38188, CG5216, D.mel1, DSir2, Dmel\CG5216, ...

Rosenberg, M.I. et al., Newman, B.L. et al., Frankel, S. et al., Santoso, B. et al., Barlow, A.L. et al.

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High impact information on Sir2

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination [1].
We find that the Drosophila homolog of Sir2 (dSir2) also encodes deacetylase activity and is required for heterochromatic silencing, but unlike ySir2, is not required for silencing at telomeres [1].
dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster [2].
In a two-hybrid screen for proteins that interact with the Drosophila CREB-binding protein (dCBP), a known histone acetyltransferase and transcriptional coactivator, we identified the Drosophila homolog of a yeast chromatin regulator, Sir2 [3].
Hence, the mechanism of transcriptional repression by p300 is distinct from that of histone H1, PARP-1 or Sir2 [4].

Other interactions of Sir2

Two highly conserved histone deacetylases, Sir2 and Rpd3, have been linked to caloric restriction and the extension of longevity [5].

References

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Rosenberg, M.I., Parkhurst, S.M. Cell (2002) [Pubmed]
dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Barlow, A.L., van Drunen, C.M., Johnson, C.A., Tweedie, S., Bird, A., Turner, B.M. Exp. Cell Res. (2001) [Pubmed]
A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span. Newman, B.L., Lundblad, J.R., Chen, Y., Smolik, S.M. Genetics (2002) [Pubmed]
Reconstitution of chromatin transcription with purified components reveals a chromatin-specific repressive activity of p300. Santoso, B., Kadonaga, J.T. Nat. Struct. Mol. Biol. (2006) [Pubmed]
Drosophila longevity is not affected by heterochromatin-mediated gene silencing. Frankel, S., Rogina, B. Aging Cell (2005) [Pubmed]

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