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Gene Review

Sir2  -  CG5216 gene product from transcript CG5216-RA

Drosophila melanogaster

Synonyms: BEST:LD38188, CG5216, D.mel1, DSir2, Dmel\CG5216, ...
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High impact information on Sir2

  • Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination [1].
  • We find that the Drosophila homolog of Sir2 (dSir2) also encodes deacetylase activity and is required for heterochromatic silencing, but unlike ySir2, is not required for silencing at telomeres [1].
  • dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster [2].
  • In a two-hybrid screen for proteins that interact with the Drosophila CREB-binding protein (dCBP), a known histone acetyltransferase and transcriptional coactivator, we identified the Drosophila homolog of a yeast chromatin regulator, Sir2 [3].
  • Hence, the mechanism of transcriptional repression by p300 is distinct from that of histone H1, PARP-1 or Sir2 [4].

Other interactions of Sir2


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