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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Caloric Restriction

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Disease relevance of Caloric Restriction


Psychiatry related information on Caloric Restriction


High impact information on Caloric Restriction

  • We summarize the current knowledge of the Sir2 homologs from different organisms, and finally we discuss the role of Sir2 in caloric restriction and aging [8].
  • Effect of slight plasma glucose decrease on glycosylated hemoglobin in healthy subjects during caloric restriction [9].
  • The age-associated increase in expression of p16INK4a and Arf is attenuated in the kidney, ovary, and heart by caloric restriction, and this decrease correlates with diminished expression of an in vivo marker of senescence, as well as decreased pathology of those organs [10].
  • After a 2-week caloric restriction, BP elevation is reversed in nontransgenic littermates with the A(y) allele, in parallel with a reduction in plasma leptin concentrations, but is sustained in transgenic mice overexpressing leptin with the A(y) allele, which remain hyperleptinemic [11].
  • While their metabolic parameters significantly changed (decrease in insulinemia, glycemia, and resting metabolic rate and increase in plasma ketone bodies), the caloric restriction did not modify the leptin mRNA level in the adipose tissue [12].

Chemical compound and disease context of Caloric Restriction


Biological context of Caloric Restriction


Anatomical context of Caloric Restriction


Associations of Caloric Restriction with chemical compounds


Gene context of Caloric Restriction

  • In contrast, we find that food restriction does not further increase the life span of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes [32].
  • Furthermore, deletion of RTG3, a downstream mediator in this pathway, and caloric restriction had an additive effect, resulting in the largest increase (123%) in longevity described thus far in yeast [33].
  • Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life span and delay age-related diseases [34].
  • Caloric restriction does not reverse aging-related changes in hippocampal BDNF [35].
  • Deletion of the RPD3 gene extended life span, and there was no additive effect of caloric restriction [36].

Analytical, diagnostic and therapeutic context of Caloric Restriction


  1. The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. Wood, P.D., Stefanick, M.L., Williams, P.T., Haskell, W.L. N. Engl. J. Med. (1991) [Pubmed]
  2. Overweight postmenopausal women lose bone with moderate weight reduction and 1 g/day calcium intake. Riedt, C.S., Cifuentes, M., Stahl, T., Chowdhury, H.A., Schlussel, Y., Shapses, S.A. J. Bone Miner. Res. (2005) [Pubmed]
  3. The effect of fenfluramine and caloric restriction on carbohydrate homeostasis in patients with lipodystrophy. Wilson, T.A., Melton, T., Clarke, W.L. Diabetes Care (1983) [Pubmed]
  4. Diminished effect of caloric restriction on control of hyperglycemia with increasing known duration of type II diabetes mellitus. Nagulesparan, M., Savage, P.J., Bennion, L.J., Unger, R.H., Bennett, P.H. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  5. Relative role of caloric restriction and exercise training upon susceptibility to isoproterenol-induced myocardial infarction in male rats. Crandall, D.L., Feirer, R.P., Griffith, D.R., Beitz, D.C. Am. J. Clin. Nutr. (1981) [Pubmed]
  6. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Mattson, M.P., Chan, S.L., Duan, W. Physiol. Rev. (2002) [Pubmed]
  7. Long-term weight control study. IV (weeks 156 to 190). The second double-blind phase. Weintraub, M., Sundaresan, P.R., Schuster, B., Averbuch, M., Stein, E.C., Cox, C., Byrne, L. Clin. Pharmacol. Ther. (1992) [Pubmed]
  8. The Sir2 family of protein deacetylases. Blander, G., Guarente, L. Annu. Rev. Biochem. (2004) [Pubmed]
  9. Effect of slight plasma glucose decrease on glycosylated hemoglobin in healthy subjects during caloric restriction. Ktorza, A., Baigts, F., Fumeron, F., Rizkalla, S., Kinebanyan, F.M. N. Engl. J. Med. (1985) [Pubmed]
  10. Ink4a/Arf expression is a biomarker of aging. Krishnamurthy, J., Torrice, C., Ramsey, M.R., Kovalev, G.I., Al-Regaiey, K., Su, L., Sharpless, N.E. J. Clin. Invest. (2004) [Pubmed]
  11. Pathophysiological role of leptin in obesity-related hypertension. Aizawa-Abe, M., Ogawa, Y., Masuzaki, H., Ebihara, K., Satoh, N., Iwai, H., Matsuoka, N., Hayashi, T., Hosoda, K., Inoue, G., Yoshimasa, Y., Nakao, K. J. Clin. Invest. (2000) [Pubmed]
  12. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. Vidal, H., Auboeuf, D., De Vos, P., Staels, B., Riou, J.P., Auwerx, J., Laville, M. J. Clin. Invest. (1996) [Pubmed]
  13. Retention of estradiol negative feedback relationship to LH predicts ovulation in response to caloric restriction and weight loss in obese patients with polycystic ovary syndrome. van Dam, E.W., Roelfsema, F., Veldhuis, J.D., Hogendoorn, S., Westenberg, J., Helmerhorst, F.M., Frölich, M., Krans, H.M., Meinders, A.E., Pijl, H. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  14. Role of sibutramine in the treatment of obese Type 2 diabetic patients receiving sulphonylurea therapy. Serrano-Rios, M., Melchionda, N., Moreno-Carretero, E. Diabet. Med. (2002) [Pubmed]
  15. Stress and hunger alter the anorectic efficacy of fluoxetine in binge-eating rats with a history of caloric restriction. Placidi, R.J., Chandler, P.C., Oswald, K.D., Maldonado, C., Wauford, P.K., Boggiano, M.M. The International journal of eating disorders. (2004) [Pubmed]
  16. Protection against chronic cadmium toxicity by caloric restriction. Shaikh, Z.A., Jordan, S.A., Tang, W. Toxicology (1999) [Pubmed]
  17. Substance use among women with eating disorders. Wiederman, M.W., Pryor, T. The International journal of eating disorders. (1996) [Pubmed]
  18. Plasma endothelin-1 levels in obese hypertensive and normotensive men. Ferri, C., Bellini, C., Desideri, G., Di Francesco, L., Baldoncini, R., Santucci, A., De Mattia, G. Diabetes (1995) [Pubmed]
  19. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. Shiojima, I., Yefremashvili, M., Luo, Z., Kureishi, Y., Takahashi, A., Tao, J., Rosenzweig, A., Kahn, C.R., Abel, E.D., Walsh, K. J. Biol. Chem. (2002) [Pubmed]
  20. Protein profiling of 3T3-L1 adipocyte differentiation and (tumor necrosis factor alpha-mediated) starvation. Renes, J., Bouwman, F., Noben, J.P., Evelo, C., Robben, J., Mariman, E. Cell. Mol. Life Sci. (2005) [Pubmed]
  21. Zinc replenishment reduces esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in zinc-deficient rats. Fong, L.Y., Farber, J.L., Magee, P.N. Carcinogenesis (1998) [Pubmed]
  22. Regulation of gene expression during severe caloric restriction: lack of induction of p85 alpha phosphatidylinositol 3-kinase mRNA in skeletal muscle of patients with type II (non-insulin-dependent) diabetes mellitus. Andreelli, F., Laville, M., Vega, N., Riou, J.P., Vidal, H. Diabetologia (2000) [Pubmed]
  23. Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat T cells. Pahlavani, M.A., Vargas, D.M. Proc. Soc. Exp. Biol. Med. (2000) [Pubmed]
  24. Depression in the quantity of intestinal secretory IgA and in the expression of the polymeric immunoglobulin receptor in caloric deficiency of the weanling mouse. Ha, C.L., Woodward, B. Lab. Invest. (1998) [Pubmed]
  25. Relationship between training frequency and subcutaneous and visceral fat in women. Abe, T., Kawakami, Y., Sugita, M., Fukunaga, T. Medicine and science in sports and exercise. (1997) [Pubmed]
  26. Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice. Vega, V.L., De Cabo, R., De Maio, A. Shock (2004) [Pubmed]
  27. Effects of obesity and caloric intake on biliary lipid metabolism in man. Bennion, L.J., Grundy, S.M. J. Clin. Invest. (1975) [Pubmed]
  28. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. Frederich, R.C., Löllmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, B.B., Lowell, B.B., Flier, J.S. J. Clin. Invest. (1995) [Pubmed]
  29. Interpopulational differences in progesterone levels during conception and implantation in humans. Vitzthum, V.J., Spielvogel, H., Thornburg, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  30. Effects of caloric restriction and dietary fat on epithelial cell proliferation in rat colon. Steinbach, G., Kumar, S.P., Reddy, B.S., Lipkin, M., Holt, P.R. Cancer Res. (1993) [Pubmed]
  31. Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat. Klurfeld, D.M., Weber, M.M., Kritchevsky, D. Cancer Res. (1987) [Pubmed]
  32. The genetics of caloric restriction in Caenorhabditis elegans. Lakowski, B., Hekimi, S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  33. An intervention resembling caloric restriction prolongs life span and retards aging in yeast. Jiang, J.C., Jaruga, E., Repnevskaya, M.V., Jazwinski, S.M. FASEB J. (2000) [Pubmed]
  34. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Al-Regaiey, K.A., Masternak, M.M., Bonkowski, M., Sun, L., Bartke, A. Endocrinology (2005) [Pubmed]
  35. Caloric restriction does not reverse aging-related changes in hippocampal BDNF. Newton, I.G., Forbes, M.E., Legault, C., Johnson, J.E., Brunso-Bechtold, J.K., Riddle, D.R. Neurobiol. Aging (2005) [Pubmed]
  36. Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. Jiang, J.C., Wawryn, J., Shantha Kumara, H.M., Jazwinski, S.M. Exp. Gerontol. (2002) [Pubmed]
  37. Adrenalectomy reduces but does not reverse obesity in ob/ob mice. Dubuc, P.U., Wilden, N.J. International journal of obesity. (1986) [Pubmed]
  38. Effects of changes in calorie intake on intestinal nutrient uptake and transporter mRNA levels in aged mice. Casirola, D.M., Lan, Y., Ferraris, R.P. J. Gerontol. A Biol. Sci. Med. Sci. (1997) [Pubmed]
  39. Hypocaloric diets and ketogenesis in the management of obese gestational diabetic women. Knopp, R.H., Magee, M.S., Raisys, V., Benedetti, T., Bonet, B. Journal of the American College of Nutrition. (1991) [Pubmed]
  40. Animal models and possible human application of immunological restoration in the elderly. Hirokawa, K., Utsuyama, M. Mech. Ageing Dev. (2002) [Pubmed]
  41. Caloric restriction perturbs the pituitary-ovarian axis and inhibits mouse mammary tumor virus production in a high-spontaneous-mammary-tumor-incidence mouse strain (C3H/SHN). Koizumi, A., Masuda, H., Wada, Y., Tsukada, M., Kawamura, K., Kamiyama, S., Walford, R.L. Mech. Ageing Dev. (1989) [Pubmed]
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