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Gene Review:

HDAC6 - CG6170 gene product from transcript CG6170-RA

Drosophila melanogaster

Synonyms: CG6170, DHDAC2, DmHDAC2, Dmel\CG6170, HDAC, ...

Chen, T. et al., Tao, D. et al., Gao, L. et al., Barlow, A.L. et al.

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High impact information on HDAC6

dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster [1].
In this study, we investigated the influences of histone acetylation modification on changes in structure of polytene chromosomes and in expression of hsp70 gene in Drosophila melanogaster, by using histone deacetylase (HDAC) inhibitors Trichostatin A (TSA) and sodium butyrate (BuA), and the heat shock treatment of larvae of the flies [2].

Associations of HDAC6 with chemical compounds

In present study, we investigated the influence of histone acetylation modification on the expression of hsp22 gene and the lifespan in Drosophila melanogaster using histone deacetylase (HDAC) inhibitor Trichostatin A (TSA) [3].

Analytical, diagnostic and therapeutic context of HDAC6

Co-immunoprecipitation experiments indicate that HDAC11 may be present in protein complexes that also contain HDAC6 [4].

References

dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Barlow, A.L., van Drunen, C.M., Johnson, C.A., Tweedie, S., Bird, A., Turner, B.M. Exp. Cell Res. (2001) [Pubmed]
Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. Chen, T., Sun, H., Lu, J., Zhao, Y., Tao, D., Li, X., Huang, B. Arch. Biochem. Biophys. (2002) [Pubmed]
Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. Tao, D., Lu, J., Sun, H., Zhao, Y.M., Yuan, Z.G., Li, X.X., Huang, B.Q. Acta Biochim. Biophys. Sin. (Shanghai) (2004) [Pubmed]
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. Gao, L., Cueto, M.A., Asselbergs, F., Atadja, P. J. Biol. Chem. (2002) [Pubmed]

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