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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NC2beta  -  Negative Cofactor 2beta

Drosophila melanogaster

Synonyms: BG:DS00929.3, CG4185, Dmel\CG4185, Down-regulator of transcription 1, Dr1, ...
 
 
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High impact information on NC2beta

  • The purified factor was found to be the Drosophila homolog of the transcriptional repressor known as NC2 or Dr1-Drap1 [1].
  • These studies reveal that NC2 (Dr1-Drap1) is a bifunctional basal transcription factor that differentially regulates gene transcription through DPE or TATA box motifs [1].
  • The majority of the Dr1 and DrMio revertants are embryonic lethal in trans, mutant embryos exhibiting trachea that fail to join the Filzkörper, thus revealing a role for the Drop gene in embryogenesis [2].

References

  1. A basal transcription factor that activates or represses transcription. Willy, P.J., Kobayashi, R., Kadonaga, J.T. Science (2000) [Pubmed]
  2. The dominant Drop eye mutations of Drosophila melanogaster define two loci implicated in normal eye development. Tearle, R., Tomlinson, A., Saint, R. Mol. Gen. Genet. (1994) [Pubmed]
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