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Gene Review:

IGHA2 - immunoglobulin heavy constant alpha 2 (A2m...

Homo sapiens

Synonyms: Ig alpha-2 chain C region

Keyeux, G. et al., Wagner, B. et al., Bensmana, M. et al.

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High impact information on IGHA2

In this report we define ten Salpha1 IGHA1 (*S5-*S14) and nine Salpha2 IGHA2 (*S10-*S18) newly found alleles of the human immunoglobulin switch alpha 1 and switch alpha 2 regions, respectively, in Colombian Indian, Black and Mestizo populations, and a complete list of the SacI and PvuII alleles so far identified as given [1].

Biological context of IGHA2

The coding nucleotide sequence of the secreted form of the equine IGHA gene shares around 72% identity with the human IGHA1 and IGHA2 genes, as well as the bovine, ovine, porcine and canine IGHA genes, without distinct preference for any of these species [2].
We have determined the nucleotide sequences of the human IGHG3, IGHA1, and IGHA2 membrane exons isolated from genomic DNA libraries [3].

References

New allele variants of the immunoglobulin switch (Salpha) regions. Keyeux, G., Bernal, J.E. Hum. Genet. (1996) [Pubmed]
Characterization of the horse (Equus caballus) IGHA gene. Wagner, B., Greiser-Wilke, I., Antczak, D.F. Immunogenetics (2003) [Pubmed]
Gene segments encoding membrane domains of the human immunoglobulin gamma 3 and alpha chains. Bensmana, M., Lefranc, M.P. Immunogenetics (1990) [Pubmed]

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