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Gene Review

ADRA1D  -  adrenoceptor alpha 1D

Homo sapiens

Synonyms: ADRA1, ADRA1A, ADRA1R, ALPHA1, Alpha-1A adrenergic receptor, ...
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Disease relevance of ADRA1D

  • alpha 1-Adrenergic receptors play important roles in mediating a wide range of important cellular responses; regulation of expression of these receptors may have pathophysiological significance in diseases such as hypertension [1].
  • Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness [2].
  • Hereditary hyperekplexia, an autosomal dominant neurologic disorder characterized by an exaggerated startle reflex and neonatal hypertonia, can be caused by mutations in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor (GLRA1) [3].
  • Elevated serum thymosin alpha 1 levels associated with evidence of immune dysregulation in male homosexuals with a history of infectious diseases or Kaposi's sarcoma [4].
  • The transcription rate of genes like albumin and alpha1-antitrypsin is reduced, while the gene coding for phenylalanine hydroxylase is totally silent, giving rise to phenylketonuria [5].

Psychiatry related information on ADRA1D

  • Addition of either alpha 1-anti-chymotrypsin or apoE to the A beta peptide promoted a 10- to 20-fold increase in filament formation, with apoE-4, the isoform recently linked to the development of late-onset Alzheimer's disease, showing the highest catalytic activity [6].
  • BACKGROUND: Persons with posttraumatic stress disorder (PTSD) whose trauma-related nightmares improve or resolve with bedtime administration of the alpha-1 adrenergic antagonist prazosin often continue to experience PTSD symptoms during the day [7].
  • This reduction of prepulse inhibition is consistent with the synergistic effect of D1 and D2 DA receptor stimulation noted in studies of dopaminergic influences on stereotyped behavior in rats [8].
  • PURPOSE: We determined whether an extract from the bark of the tree Aspidosperma quebracho blanco, which is used as a prescription drug to treat erectile dysfunction in some countries, can bind to human penile alpha1 and alpha2-adrenoceptors, and cloned human alpha-adrenoceptor subtypes [9].
  • The results suggest that presynaptic alpha 2- or postsynaptic alpha 1-beta-adrenoceptor sensitivity is impaired in panic disorder [10].

High impact information on ADRA1D

  • We report that an Ala322Asp mutation in GABRA1, encoding the alpha1 subunit of the gamma-aminobutyric acid receptor subtype A (GABA(A)), is found in affected individuals of a large French Canadian family with juvenile myoclonic epilepsy [11].
  • All 87 patients with the deletional type of hemoglobin H were double heterozygotes in whom there was a deletion of both alpha-globin genes from one chromosome, plus a deletion of the alpha1 or alpha2 gene from the other chromosome (--/alpha- or --/-alpha) [12].
  • Bax consists of 9 alpha helices where the assembly of helices alpha1 through alpha 8 resembles that of the apoptosis inhibitor, Bcl-x(L) [13].
  • Mutation analysis of this new alpha1-subunit gene, CACNA1F, in 20 families with incomplete CSNB revealed six different mutations that are all predicted to cause premature protein truncation [2].
  • The beta- and alpha 1-binding motifs are conserved, and all beta subunits can stimulate current amplitude, voltage dependence, and kinetics when coexpressed with various alpha 1 subunits [14].

Chemical compound and disease context of ADRA1D


Biological context of ADRA1D

  • Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13 [20].
  • alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1 [21].
  • In an effort to bridge the gap between molecular biology and pathophysiology, we have chosen a model smooth muscle system, the human prostate, and investigated the role of alpha 1 subtypes in this tissue [22].
  • Radioligand binding results revealed that there were no significant differences in the K(d) between ureteral regions, while a heterogeneous distribution of alpha1 AR binding sites was detected, with the highest density of alpha1 ARs in the distal ureter and a lower similar density in the medial and proximal ureters [23].
  • Nucleotide sequence analysis revealed clone H318/3 was 78% homologous to a rat alpha 1A adrenergic receptor with homology being 95% when comparisons were made in the region that lies between the first to the seventh transmembrane domains [24].

Anatomical context of ADRA1D

  • CONCLUSIONS: Human ureter was endowed with each alpha1 AR subtype, although alpha1D and alpha1A ARs were prevalent over alpha1B ARs [23].
  • The current study investigates the role of the alpha-1 adrenoceptor on human mesangial cell scarring [25].
  • We wondered if glucocorticoids might induce expression of alpha 1 adrenergic receptors, which could contribute to the increased sensitivity of vascular smooth muscle to catecholamines that may occur with glucocorticoid excess [26].
  • Taken together, these results show that in differentiated human adipocytes: (1) alpha 1- and beta-adrenergic stimulations induce [Ca2+]i increases with different kinetics and amplitudes; (2) there is a beta 3-adrenergic response similar to the beta 1- or beta 2-adrenergic responses; and (3) there is a marked adrenoceptor heterogeneity [27].
  • In the present work we studied cell-specific localizations of alpha1 adrenergic receptor subtype mRNA (alpha 1a, alpha 1b, alpha 1d), and alpha2 adrenergic receptor subtype mRNA (alpha 2a, alpha 2b, alpha 2c) by in situ hybridization on cryostat sections of human cerebellum (cortical layers and dentate nucleus) [28].

Associations of ADRA1D with chemical compounds


Physical interactions of ADRA1D

  • We generated alanine substitution mutants of hIFNAR2-IgG and determined that regions of hIFNAR2 are important for the binding of these blocking mAbs and hIFN-alpha2/alpha1 [31].
  • These findings indicate that the carboxy-terminal third of Gi alpha 1 interacts with SSTR3 and is important in transmitting the signal of SSTR3 activation to adenylyl cyclase [32].
  • Human alpha1-acid glycoprotein binds to CCR5 expressed on the plasma membrane of human primary macrophages [33].
  • The AMP-activated protein kinase (AMPK) is a heterotrimer composed of different isoforms of the alphabetagamma subunits, where the alpha1 catalytic subunit binds CFTR [34].
  • These results indicate that human SSTR2 is functionally coupled to Gi alpha 1 protein but not to Gi alpha 2 or Gi alpha 3 when expressed in CHO cells [35].

Enzymatic interactions of ADRA1D

  • In the thigh muscle, the alpha AMPK subunits became progressively more phosphorylated on Thr(172) during exercise eliciting a parallel increase in alpha2 but not alpha1 AMPK activity [36].
  • In addition, I alone or in the presence of C4-bp fails to cleave the alpha 1-chain of C4b in the stabilized C4b, 2a complex [37].
  • Sil cells had decreased sialyltransferase activity that catalyzed the transfer of sialic acid residues from CMP-N-acetylneuraminic acid to glycoprotein acceptors containing Gal beta 1 leads to 3GalNAc alpha 1 leads to O-Ser(Thr) chain [38].
  • Reaction dynamics of G-protein catalyzed hydrolysis of GTP as viewed by X-ray crystallographic snapshots of Gi alpha 1 [39].
  • While numerous studies have demonstrated that the myeloperoxidase system found in neutrophils can oxidize and functionally inactivate alpha 1-proteinase inhibitor in vitro, there is little direct evidence that this phenomenon is relevant in vivo [40].

Co-localisations of ADRA1D


Regulatory relationships of ADRA1D


Other interactions of ADRA1D


Analytical, diagnostic and therapeutic context of ADRA1D


  1. Cycloheximide induces the alpha 1B adrenergic receptor gene by activation of transcription in DDT1 MF-2 smooth muscle cells. Hu, Z.W., Hoffman, B.B. Mol. Pharmacol. (1993) [Pubmed]
  2. Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Bech-Hansen, N.T., Naylor, M.J., Maybaum, T.A., Pearce, W.G., Koop, B., Fishman, G.A., Mets, M., Musarella, M.A., Boycott, K.M. Nat. Genet. (1998) [Pubmed]
  3. A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse. Ryan, S.G., Buckwalter, M.S., Lynch, J.W., Handford, C.A., Segura, L., Shiang, R., Wasmuth, J.J., Camper, S.A., Schofield, P., O'Connell, P. Nat. Genet. (1994) [Pubmed]
  4. Elevated serum thymosin alpha 1 levels associated with evidence of immune dysregulation in male homosexuals with a history of infectious diseases or Kaposi's sarcoma. Hersh, E.M., Reuben, J.M., Rios, A., Mansell, P.W., Newell, G.R., McClure, J.E., Goldstein, A.L. N. Engl. J. Med. (1983) [Pubmed]
  5. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Pontoglio, M., Barra, J., Hadchouel, M., Doyen, A., Kress, C., Bach, J.P., Babinet, C., Yaniv, M. Cell (1996) [Pubmed]
  6. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Ma, J., Yee, A., Brewer, H.B., Das, S., Potter, H. Nature (1994) [Pubmed]
  7. Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder. Taylor, F.B., Lowe, K., Thompson, C., McFall, M.M., Peskind, E.R., Kanter, E.D., Allison, N., Williams, J., Martin, P., Raskind, M.A. Biol. Psychiatry (2006) [Pubmed]
  8. A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia. Peng, R.Y., Mansbach, R.S., Braff, D.L., Geyer, M.A. Neuropsychopharmacology (1990) [Pubmed]
  9. An extract from the bark of Aspidosperma quebracho blanco binds to human penile alpha-adrenoceptors. Sperling, H., Lorenz, A., Krege, S., Arndt, R., Michel, M.C. J. Urol. (2002) [Pubmed]
  10. Alpha 2-adrenergic receptor sensitivity in panic disorder: II. Cortisol response to clonidine stimulation in panic disorder. Brambilla, F., Bellodi, L., Arancio, C., Nobile, P., Perna, G. Psychoneuroendocrinology (1995) [Pubmed]
  11. Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Cossette, P., Liu, L., Brisebois, K., Dong, H., Lortie, A., Vanasse, M., Saint-Hilaire, J.M., Carmant, L., Verner, A., Lu, W.Y., Wang, Y.T., Rouleau, G.A. Nat. Genet. (2002) [Pubmed]
  12. Genetic and clinical features of hemoglobin H disease in Chinese patients. Chen, F.E., Ooi, C., Ha, S.Y., Cheung, B.M., Todd, D., Liang, R., Chan, T.K., Chan, V. N. Engl. J. Med. (2000) [Pubmed]
  13. Structure of Bax: coregulation of dimer formation and intracellular localization. Suzuki, M., Youle, R.J., Tjandra, N. Cell (2000) [Pubmed]
  14. Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Burgess, D.L., Jones, J.M., Meisler, M.H., Noebels, J.L. Cell (1997) [Pubmed]
  15. Modulation of GABAA receptors by tyrosine phosphorylation. Moss, S.J., Gorrie, G.H., Amato, A., Smart, T.G. Nature (1995) [Pubmed]
  16. Value of plasma alpha-1-acid glycoprotein assay in the detection of human colorectal cancer: comparison with carcinoembryonic antigen. Chu, C.Y., Lai, L.T., Pokala, H.P. J. Natl. Cancer Inst. (1982) [Pubmed]
  17. Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics. Liebhaber, S.A., Kan, Y.W. J. Clin. Invest. (1981) [Pubmed]
  18. Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail. Ivaska, J., Reunanen, H., Westermarck, J., Koivisto, L., Kähäri, V.M., Heino, J. J. Cell Biol. (1999) [Pubmed]
  19. Increased alpha-1-acid glycoprotein and lidocaine disposition in myocardial infarction. Routledge, P.A., Stargel, W.W., Wagner, G.S., Shand, D.G. Ann. Intern. Med. (1980) [Pubmed]
  20. Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13. Yang-Feng, T.L., Han, H., Lomasney, J.W., Caron, M.G. Cytogenet. Cell Genet. (1994) [Pubmed]
  21. alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1. Shibata, K., Katsuma, S., Koshimizu, T., Shinoura, H., Hirasawa, A., Tanoue, A., Tsujimoto, G. J. Biol. Chem. (2003) [Pubmed]
  22. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Forray, C., Bard, J.A., Wetzel, J.M., Chiu, G., Shapiro, E., Tang, R., Lepor, H., Hartig, P.R., Weinshank, R.L., Branchek, T.A. Mol. Pharmacol. (1994) [Pubmed]
  23. Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter. Sigala, S., Dellabella, M., Milanese, G., Fornari, S., Faccoli, S., Palazzolo, F., Peroni, A., Mirabella, G., Cunico, S.C., Spano, P., Muzzonigro, G. Neurourology and urodynamics. (2005) [Pubmed]
  24. Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. Bruno, J.F., Whittaker, J., Song, J.F., Berelowitz, M. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  25. The role of the {alpha}-1 adrenoceptor in modulating human mesangial cell matrix production. Pawluczyk, I.Z., Patel, S.R., Harris, K.P. Nephrol. Dial. Transplant. (2006) [Pubmed]
  26. Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. Sakaue, M., Hoffman, B.B. J. Clin. Invest. (1991) [Pubmed]
  27. Adrenoceptor heterogeneity in human white adipocytes differentiated in culture as assessed by cytosolic free calcium measurements. Seydoux, J., Muzzin, P., Moinat, M., Pralong, W., Girardier, L., Giacobino, J.P. Cell. Signal. (1996) [Pubmed]
  28. Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Schambra, U.B., Mackensen, G.B., Stafford-Smith, M., Haines, D.E., Schwinn, D.A. Neuroscience (2005) [Pubmed]
  29. Chromosomal organization of adrenergic receptor genes. Yang-Feng, T.L., Xue, F.Y., Zhong, W.W., Cotecchia, S., Frielle, T., Caron, M.G., Lefkowitz, R.J., Francke, U. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  30. Agonist regulation of alpha 1B-adrenergic receptor subcellular distribution and function. Fonseca, M.I., Button, D.C., Brown, R.D. J. Biol. Chem. (1995) [Pubmed]
  31. Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2. Chuntharapai, A., Gibbs, V., Lu, J., Ow, A., Marsters, S., Ashkenazi, A., De Vos, A., Jin Kim, K. J. Immunol. (1999) [Pubmed]
  32. Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation. Law, S.F., Zaina, S., Sweet, R., Yasuda, K., Bell, G.I., Stadel, J., Reisine, T. Mol. Pharmacol. (1994) [Pubmed]
  33. Human alpha1-acid glycoprotein binds to CCR5 expressed on the plasma membrane of human primary macrophages. Atemezem, A., Mbemba, E., Vassy, R., Slimani, H., Saffar, L., Gattegno, L. Biochem. J. (2001) [Pubmed]
  34. NDPK-A (but not NDPK-B) and AMPK alpha1 (but not AMPK alpha2) bind the cystic fibrosis transmembrane conductance regulator in epithelial cell membranes. Crawford, R.M., Treharne, K.J., Best, O.G., Riemen, C.E., Muimo, R., Gruenert, D.C., Arnaud-Dabernat, S., Daniel, J.Y., Mehta, A. Cell. Signal. (2006) [Pubmed]
  35. Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein. Kagimoto, S., Yamada, Y., Kubota, A., Someya, Y., Ihara, Y., Yasuda, K., Kozasa, T., Imura, H., Seino, S., Seino, Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  36. Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Wojtaszewski, J.F., Mourtzakis, M., Hillig, T., Saltin, B., Pilegaard, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  37. Regulation and deregulation of the fluid-phase classical pathway C3 convertase. Gigli, I., Sorvillo, J., Halbwachs-Mecarelli, L. J. Immunol. (1985) [Pubmed]
  38. Deficient cytidine monophospho-N-acetylneuraminic acid: glycoprotein sialyltransferase activity in a clone of KB cells with altered cell fusion ability. Toyama, S., Koyama, A.H., Toyama, S. J. Biol. Chem. (1983) [Pubmed]
  39. Reaction dynamics of G-protein catalyzed hydrolysis of GTP as viewed by X-ray crystallographic snapshots of Gi alpha 1. Coleman, D.E., Sprang, S.R. Meth. Enzymol. (1999) [Pubmed]
  40. Myeloperoxidase-induced inactivation of alpha 1-antiprotease in hamsters. Zaslow, M.C., Clark, R.A., Stone, P.J., Calore, J., Snider, G.L., Franzblau, C. J. Lab. Clin. Med. (1985) [Pubmed]
  41. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. Lo, H.W., Ali-Seyed, M., Wu, Y., Bartholomeusz, G., Hsu, S.C., Hung, M.C. J. Cell. Biochem. (2006) [Pubmed]
  42. Detection and measurement of alpha-fetoprotein in human breast cancer cytosol after treatment with 0.4 M potassium chloride. Sarcione, E.J., Zloty, M., Delluomo, D.S., Mizejewski, G., Jacobson, H. Cancer Res. (1983) [Pubmed]
  43. Evidence that "myofibroblast-like" cells are the cellular source of capsular collagen in hepatocellular carcinoma. Ooi, L.P., Crawford, D.H., Gotley, D.C., Clouston, A.D., Strong, R.W., Gobe, G.C., Halliday, J.W., Bridle, K.R., Ramm, G.A. J. Hepatol. (1997) [Pubmed]
  44. Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure. Böhm, M., Eschenhagen, T., Gierschik, P., Larisch, K., Lensche, H., Mende, U., Schmitz, W., Schnabel, P., Scholz, H., Steinfath, M. J. Mol. Cell. Cardiol. (1994) [Pubmed]
  45. GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Berman, D.M., Wilkie, T.M., Gilman, A.G. Cell (1996) [Pubmed]
  46. Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression. Sumi, D., Ignarro, L.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  47. Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Forsyth, C.B., Pulai, J., Loeser, R.F. Arthritis Rheum. (2002) [Pubmed]
  48. Enhanced alpha1 microglobulin secretion from Hepatitis E virus ORF3-expressing human hepatoma cells is mediated by the tumor susceptibility gene 101. Surjit, M., Oberoi, R., Kumar, R., Lal, S.K. J. Biol. Chem. (2006) [Pubmed]
  49. Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. Kopp, J., Preis, E., Said, H., Hafemann, B., Wickert, L., Gressner, A.M., Pallua, N., Dooley, S. J. Biol. Chem. (2005) [Pubmed]
  50. Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal past. Buzas, B., Belfer, I., Hipp, H., Lorincz, I., Evans, C., Phillips, G., Taubman, J., Max, M.B., Goldman, D. Mol. Genet. Genomics (2004) [Pubmed]
  51. Carvedilol-induced antagonism of angiotensin II: a matter of alpha1-adrenoceptor blockade. Batenburg, W.W., van Esch, J.H., Garrelds, I.M., Jorde, U., Lamers, J.M., Dekkers, D.H., Walther, T., Kellett, E., Milligan, G., van Kats, J.P., Danser, A.H. J. Hypertens. (2006) [Pubmed]
  52. Genomic organization and expression of the human alpha 1B-adrenergic receptor. Ramarao, C.S., Denker, J.M., Perez, D.M., Gaivin, R.J., Riek, R.P., Graham, R.M. J. Biol. Chem. (1992) [Pubmed]
  53. Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells. Leiba, M., Cahalon, L., Shimoni, A., Lider, O., Zanin-Zhorov, A., Hecht, I., Sela, U., Vlodavsky, I., Nagler, A. J. Leukoc. Biol. (2006) [Pubmed]
  54. Putative leech dopamine1-like receptor molecular characterization: sequence homologies between dopamine and serotonin leech CNS receptors explain pharmacological cross-reactivities. Salzet, B., Stefano, G.B., Verger-Bocquet, M., Salzet, M. Brain Res. Mol. Brain Res. (1998) [Pubmed]
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