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Gene Review

IGHG3  -  immunoglobulin heavy constant gamma 3 (G3m...

Homo sapiens

Synonyms: HDC, Heavy chain disease protein, Ig gamma-3 chain C region
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Disease relevance of IGHG3

  • Elsewhere, the distribution and prevalence of hyperreactive malarious splenomegaly is consistent with the distributions of IGHG3 alleles [1].
  • Despite the frequency with which this procedure is performed, the role of HDC/ASCR in the treatment of breast cancer remains undefined [2].
  • To evaluate the role of high-dose chemotherapy (HDC) followed by autologous bone marrow transplantation (ABMT) in children with poor-prognosis Burkitt's lymphoma, the European Lymphoma BMT registry was critically reviewed [3].
  • These results, although still preliminary, indicate that HDC and TBI, followed by blood stem cells autograft, which has both practical and theoretical interest over allogeneic or autologous bone marrow transplantation, deserve consideration in selected patients with multiple myeloma [4].
  • We performed a multicenter, retrospective analysis of morphologically normal pretransplant marrow or stem cell specimens from 12 patients who subsequently developed myelodysplasia after HDC [5].

Psychiatry related information on IGHG3

  • METHODS: A total of 18,435 female residents age 35 years and over in a city of Gifu Prefecture, Japan, responded in 1992 to a health questionnaire that included questions on the use of HDCP, lifestyle, and dietary habits [6].
  • Immunophenotypic analysis of marrow cells facilitates clinical decision making regarding the use of HDC/PBSCT for LHCDD patients without monoclonal protein [7].

High impact information on IGHG3


Chemical compound and disease context of IGHG3


Biological context of IGHG3


Anatomical context of IGHG3


Associations of IGHG3 with chemical compounds

  • Moreover, we show that the LAT G3m (b0, b1, c3, c5, u) coding sequence results from the conversion, in the CH3 exon, of the G3m (b0, b1, b3, b4, b5, u, v) allele, the most frequent IGHG3 gene in the Negroid populations, by the homologous region of a IGHG4 gene [18].
  • HDC was cyclophosphamide 6 g/m2, carboplatin 2 g/m2, and etoposide 625 mg/m2 with ABMT [25].
  • Eleven patients received HDC with CTX + MEL, and one patient received BU + MEL followed by ASCR [26].
  • The HDC was a combination of carmustine (BCNU), teniposide (VM-26), and melphalan [27].
  • The mean delivered dose-intensity for cisplatin was significantly greater in the high-dose arms: HDCP 41 mg/m2/wk and HDCP-M 39 mg/m2/wk, versus SDCP 23 mg/m2/wk (P = .05) [28].

Other interactions of IGHG3

  • The newly found IGHG7 gene, which has a high homology to the equine IGHG4 gene, is located between the IGHG3 and IGHG4 genes [29].
  • The five human IGHG genes consist of three constant domain exons plus one of or four hinge exon(s), the quadruplicated hinge region being characteristic of the IGHG3 gene [18].

Analytical, diagnostic and therapeutic context of IGHG3


  1. IGHG3 G and the pathogenesis of hyperreactive malarious splenomegaly. Kelly, K.M. Med. Hypotheses (1996) [Pubmed]
  2. Much ado about not...enough data: high-dose chemotherapy with autologous stem cell rescue for breast cancer. Zujewski, J., Nelson, A., Abrams, J. J. Natl. Cancer Inst. (1998) [Pubmed]
  3. High-dose chemotherapy with autologous bone marrow rescue in children with poor-risk Burkitt's lymphoma: a report from the European Lymphoma Bone Marrow Transplantation Registry. Ladenstein, R., Pearce, R., Hartmann, O., Patte, C., Goldstone, T., Philip, T. Blood (1997) [Pubmed]
  4. Treatment of aggressive multiple myeloma by high-dose chemotherapy and total body irradiation followed by blood stem cells autologous graft. Fermand, J.P., Levy, Y., Gerota, J., Benbunan, M., Cosset, J.M., Castaigne, S., Seligmann, M., Brouet, J.C. Blood (1989) [Pubmed]
  5. Detection of abnormal pretransplant clones in progenitor cells of patients who developed myelodysplasia after autologous transplantation. Abruzzese, E., Radford, J.E., Miller, J.S., Vredenburgh, J.J., Rao, P.N., Pettenati, M.J., Cruz, J.M., Perry, J.J., Amadori, S., Hurd, D.D. Blood (1999) [Pubmed]
  6. Unapproved use of high-dose combined pills in Japan: a community study on prevalence and health characteristics of the users. Nagata, C., Matsushita, Y., Inaba, S., Kawakami, N., Shimizu, H. Preventive medicine. (1997) [Pubmed]
  7. High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein. Sakakima, M., Fujigaki, Y., Tsuji, T., Fukasawa, H., Miyaji, T., Naito, K., Yamamoto, T., Yonemura, K., Ohnishi, K., Hishida, A. Intern. Med. (2005) [Pubmed]
  8. A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis. Reymer, P.W., Gagné, E., Groenemeyer, B.E., Zhang, H., Forsyth, I., Jansen, H., Seidell, J.C., Kromhout, D., Lie, K.E., Kastelein, J. Nat. Genet. (1995) [Pubmed]
  9. Gamma heavy chain disease in man. Genomic sequence reveals two noncontiguous deletions in a single gene. Alexander, A., Anicito, I., Buxbaum, J. J. Clin. Invest. (1988) [Pubmed]
  10. Immunisation with canarypox virus expressing rabies glycoprotein. Cadoz, M., Strady, A., Meignier, B., Taylor, J., Tartaglia, J., Paoletti, E., Plotkin, S. Lancet (1992) [Pubmed]
  11. A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein. Bakhshi, A., Guglielmi, P., Siebenlist, U., Ravetch, J.V., Jensen, J.P., Korsmeyer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  12. High-dose polychemotherapy with autologous bone marrow transplantation in children with relapsed lymphomas. Hartmann, O., Pein, F., Beaujean, F., Kalifa, C., Patte, C., Parmentier, C., Lemerle, J. J. Clin. Oncol. (1984) [Pubmed]
  13. Sequential prophylactic oral and empiric once-daily parenteral antibiotics for neutropenia and fever after high-dose chemotherapy and autologous bone marrow support. Gilbert, C., Meisenberg, B., Vredenburgh, J., Ross, M., Hussein, A., Perfect, J., Peters, W.P. J. Clin. Oncol. (1994) [Pubmed]
  14. Comparison of methods of measuring HER-2 in metastatic breast cancer patients treated with high-dose chemotherapy. Harris, L.N., Liotcheva, V., Broadwater, G., Ramirez, M.J., Maimonis, P., Anderson, S., Everett, T., Harpole, D., Moore, M.B., Berry, D.A., Rizzeri, D., Vredenburgh, J.J., Bentley, R.C. J. Clin. Oncol. (2001) [Pubmed]
  15. Phase II feasibility and pharmacokinetic study of concurrent administration of trastuzumab and high-dose chemotherapy in advanced HER2+ breast cancer. Nieto, Y., Vredenburgh, J.J., Shpall, E.J., Bearman, S.I., McSweeney, P.A., Chao, N., Rizzieri, D., Gasparetto, C., Matthes, S., Barón, A.E., Jones, R.B. Clin. Cancer Res. (2004) [Pubmed]
  16. Definition of the RFLP alleles in the human immunoglobulin IGHG gene locus. Ghanem, N., Lefranc, M.P., Lefranc, G. Eur. J. Immunol. (1988) [Pubmed]
  17. Gene segments encoding membrane domains of the human immunoglobulin gamma 3 and alpha chains. Bensmana, M., Lefranc, M.P. Immunogenetics (1990) [Pubmed]
  18. A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons. Huck, S., Lefranc, G., Lefranc, M.P. Immunogenetics (1989) [Pubmed]
  19. DNA sequence variability of IGHG3 alleles associated to the main G3m haplotypes in human populations. Dard, P., Lefranc, M.P., Osipova, L., Sanchez-Mazas, A. Eur. J. Hum. Genet. (2001) [Pubmed]
  20. An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. Adlersberg, J.B., Grann, V., Zucker-Franklin, D., Frangione, B., Franklin, E.C. Blood (1978) [Pubmed]
  21. High-dose chemotherapy with autologous hematopoietic progenitor-cell support as part of combined modality therapy in patients with inflammatory breast cancer. Cagnoni, P.J., Nieto, Y., Shpall, E.J., Bearman, S.I., Barón, A.E., Ross, M., Matthes, S., Dunbar, S.E., Jones, R.B. J. Clin. Oncol. (1998) [Pubmed]
  22. Thiotepa-based high-dose chemotherapy with autologous stem-cell rescue in patients with recurrent or progressive CNS germ cell tumors. Modak, S., Gardner, S., Dunkel, I.J., Balmaceda, C., Rosenblum, M.K., Miller, D.C., Halpern, S., Finlay, J.L. J. Clin. Oncol. (2004) [Pubmed]
  23. Effect of CD34(+) cell dose on resource utilization in patients after high-dose chemotherapy with peripheral-blood stem-cell support. Schulman, K.A., Birch, R., Zhen, B., Pania, N., Weaver, C.H. J. Clin. Oncol. (1999) [Pubmed]
  24. Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors. Wessler, S., Höcker, M., Fischer, W., Wang, T.C., Rosewicz, S., Haas, R., Wiedenmann, B., Meyer, T.F., Naumann, M. J. Biol. Chem. (2000) [Pubmed]
  25. Tandem autotransplantation for the treatment of metastatic breast cancer. Broun, E.R., Sridhara, R., Sledge, G.W., Loesch, D., Kneebone, P.H., Hanna, M., Hromas, R., Cornetta, K., Einhorn, L.H. J. Clin. Oncol. (1995) [Pubmed]
  26. High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas. Gururangan, S., McLaughlin, C., Quinn, J., Rich, J., Reardon, D., Halperin, E.C., Herndon, J., Fuchs, H., George, T., Provenzale, J., Watral, M., McLendon, R.E., Friedman, A., Friedman, H.S., Kurtzberg, J., Vredenbergh, J., Martin, P.L. J. Clin. Oncol. (2003) [Pubmed]
  27. Repeated high-dose chemotherapy followed by purged autologous bone marrow transplantation as consolidation therapy in metastatic neuroblastoma. Hartmann, O., Benhamou, E., Beaujean, F., Kalifa, C., Lejars, O., Patte, C., Behard, C., Flamant, F., Thyss, A., Deville, A. J. Clin. Oncol. (1987) [Pubmed]
  28. Evaluation of cisplatin intensity in metastatic non-small-cell lung cancer: a phase III study of the Southwest Oncology Group. Gandara, D.R., Crowley, J., Livingston, R.B., Perez, E.A., Taylor, C.W., Weiss, G., Neefe, J.R., Hutchins, L.F., Roach, R.W., Grunberg, S.M. J. Clin. Oncol. (1993) [Pubmed]
  29. The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse. Wagner, B., Miller, D.C., Lear, T.L., Antczak, D.F. J. Immunol. (2004) [Pubmed]
  30. Rifampin does not improve the efficacy of quinolone antibacterial prophylaxis in neutropenic cancer patients: results of a randomized clinical trial. Gomez-Martin, C., Solá, C., Hornedo, J., Perea, S., Lumbreras, C., Valentí, V., Arcediano, A., Rodriguez, M., Salazar, R., Cortés-Funes, H., Hidalgo, M. J. Clin. Oncol. (2000) [Pubmed]
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