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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RTN4RL2  -  reticulon 4 receptor-like 2

Homo sapiens

Synonyms: NGRH1, NGRL3, NgR2, Nogo receptor-like 3, Nogo-66 receptor homolog 1, ...
 
 
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Disease relevance of RTN4RL2

  • Here we exploit the same immune repertoires by phage display technology to generate rabbit monoclonal antibodies (mAbs) with nanomolar affinity to epitopes that are specific for NgR1 and NgR2, respectively, but at the same time conserved between mouse, rat, and human orthologs [1].
 

High impact information on RTN4RL2

  • NgR1, NgR2, and NgR3 which constitute the Nogo-66 receptor family are primarily expressed by neurons in the central nervous system (CNS) and believed to limit axonal growth and sprouting following CNS injury [1].
  • This may result from the influence of coreceptors in the form of gangliosides or from MAG-specific neuronal receptors such as NgR2 [2].

References

  1. Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector. Hofer, T., Tangkeangsirisin, W., Kennedy, M.G., Mage, R.G., Raiker, S.J., Venkatesh, K., Lee, H., Giger, R.J., Rader, C. J. Immunol. Methods (2007) [Pubmed]
  2. Myelin-associated glycoprotein-mediated signaling in central nervous system pathophysiology. Chen, Y., Aulia, S., Tang, B.L. Mol. Neurobiol. (2006) [Pubmed]
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