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Gene Review

Grip71  -  CG10346 gene product from transcript...

Drosophila melanogaster

Synonyms: CG10346, Dgp71WD, Dgrip71, Dmel\CG10346, Grip71wd
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High impact information on Grip71

  • In higher eukaryotes, it is assumed that microtubule nucleation at the centrosome depends on gamma-TuRCs, but the role of gamma-TuRC components remains undefined.For the first time, we analyzed the function of all four gamma-TuRC-specific subunits in Drosophila melanogaster: Dgrip75, Dgrip128, Dgrip163, and Dgp71WD [1].
  • By performing immunoprecipitations after pair-wise coexpression in Sf9 cells, we show that Dgp71WD directly interacts with the grip motif-containing gammaTuRC subunits, Dgrips84, 91, 128, and 163, suggesting that Dgp71WD may play a scaffolding role in gammaTuRC organization [2].
  • With the exception of gamma-tubulin, Dgp71WD is the only gammaTuRC component identified to date that does not contain the grip motifs, which are signature sequences conserved in gammaTuRC components [2].


  1. Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation. Vérollet, C., Colombié, N., Daubon, T., Bourbon, H.M., Wright, M., Raynaud-Messina, B. J. Cell Biol. (2006) [Pubmed]
  2. Characterization of a new gammaTuRC subunit with WD repeats. Gunawardane, R.N., Martin, O.C., Zheng, Y. Mol. Biol. Cell (2003) [Pubmed]
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