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Gene Review:

Grip75 - CG6176 gene product from transcript CG6176-RA

Drosophila melanogaster

Synonyms: 75p, CG6176, DGrip75, Dgrip75, Dgrip75/d75p, ...

Vogt, N. et al., Schnorrer, F. et al.

Schnorrer, Luschnig, Koch, Nüsslein-Volhard, Vogt, Koch, Schwarz, Schnorrer, N??sslein-Volhard,

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High impact information on Grip75

We propose that Grip75 and Grip128 are required to tether microtubules at specific microtubule-organizing centers, instead of being required for general microtubule nucleation [1].
In Drosophila, the core components of the gammaTuRC are essential for mitosis, whereas the cap component Grip75 is not required for viability but functions in bicoid RNA localization during oogenesis [1].
At stage 10b, we find gammaTub37C and Dgrip75 anteriorly concentrated and propose the formation of a microtubule-organizing center at the anterior pole of the oocyte [2].

References

The {gamma}TuRC components Grip75 and Grip128 have an essential microtubule-anchoring function in the Drosophila germline. Vogt, N., Koch, I., Schwarz, H., Schnorrer, F., N??sslein-Volhard, C. Development (2006) [Pubmed]
Gamma-tubulin37C and gamma-tubulin ring complex protein 75 are essential for bicoid RNA localization during drosophila oogenesis. Schnorrer, F., Luschnig, S., Koch, I., Nüsslein-Volhard, C. Dev. Cell (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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