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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

umuC  -  DNA polymerase V subunit UmuC

Salmonella enterica

This record was discontinued.
 
 
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Disease relevance of samB

  • Construction of a new system for separate expression of mutagenesis proteins: the abilities to promote UV mutagenesis and interchangeability of MucA', MucB, SamA' and SamB proteins in Salmonella typhimurium [1].
 

High impact information on samB

  • Surprisingly, the elevated expression of MucB alone significantly enhanced the frameshift mutagenesis induced by 1-nitropyrene and 1,8-dinitropyrene, whereas the elevated expression of SamB, MucA' and SamA' did not enhance it [2].
 

Biological context of samB

  • The mutagenesis enhancing potential of the combinations with MucB protein decreased as the expression of the proteins increased while the mutagenesis enhancing potential of the combinations with SamB protein increased together with the increase in the expression [1].

References

  1. Construction of a new system for separate expression of mutagenesis proteins: the abilities to promote UV mutagenesis and interchangeability of MucA', MucB, SamA' and SamB proteins in Salmonella typhimurium. Gruz, P., Matsui, K., Sofuni, T., Nohmi, T. Mutat. Res. (1996) [Pubmed]
  2. Roles of the mutagenesis proteins SamA'B and MucA'B in chemically induced frameshift mutagenesis in Salmonella typhimurium hisD3052. Gruz, P., Matsui, K., Sofuni, T., Nohmi, T. Mutat. Res. (1998) [Pubmed]
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