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Chemical Compound Review

CHEMBL163824     1,8-dinitropyrene

Synonyms: ACMC-1AQWO, CCRIS 2585, BIDD:ER0475, CTK1D6133, LS-129438, ...
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Disease relevance of CCRIS 2585


High impact information on CCRIS 2585


Chemical compound and disease context of CCRIS 2585


Biological context of CCRIS 2585


Anatomical context of CCRIS 2585


Associations of CCRIS 2585 with other chemical compounds


Gene context of CCRIS 2585


Analytical, diagnostic and therapeutic context of CCRIS 2585


  1. Tumorigenicity test of 1,3- and 1,8-dinitropyrene in BALB/c mice. Otofuji, T., Horikawa, K., Maeda, T., Sano, N., Izumi, K., Otsuka, H., Tokiwa, H. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene. Tahira, T., Hayashi, K., Ochiai, M., Tsuchida, N., Nagao, M., Sugimura, T. Mol. Cell. Biol. (1986) [Pubmed]
  3. Carcinogenicity of dinitropyrenes in the weanling female CD rat. Imaida, K., Lee, M.S., Wang, C.Y., King, C.M. Carcinogenesis (1991) [Pubmed]
  4. The mutagenic potency of 1,8-dinitropyrene in cultured mouse lymphoma cells. Cole, J., Arlett, C.F., Lowe, J., Bridges, B.A. Mutat. Res. (1982) [Pubmed]
  5. Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. Shimada, T., Guengerich, F.P. Cancer Res. (1990) [Pubmed]
  6. Effect of rat liver cytosolic enzymes and cofactors on mutagenicity of 1-amino-8-nitropyrene. Martire, G., Villani, G.R., Della Morte, R., Belisario, M.A., Pecce, R., Staiano, N. Carcinogenesis (1991) [Pubmed]
  7. DNA adduct formation in primary rabbit tracheal epithelial cells following treatment with 1,8-dinitropyrene and its partially reduced derivative, 1-nitro-8-nitrosopyrene. Norman, C.A., Lambert, I.B., Davison, L.M., Bryant, D.W., McCalla, D.R. Carcinogenesis (1989) [Pubmed]
  8. DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation. Heflich, R.H., Fifer, E.K., Djuric, Z., Beland, F.A. Environ. Health Perspect. (1985) [Pubmed]
  9. Dinitropyrene-resistant Salmonella typhimurium are deficient in an acetyl-CoA acetyltransferase. Orr, J.C., Bryant, D.W., McCalla, D.R., Quilliam, M.A. Chem. Biol. Interact. (1985) [Pubmed]
  10. Metabolism of 1,8-dinitropyrene by rabbit lung. Tee, L.B., Minchin, R.F., Ilett, K.F. Carcinogenesis (1988) [Pubmed]
  11. Roles of the mutagenesis proteins SamA'B and MucA'B in chemically induced frameshift mutagenesis in Salmonella typhimurium hisD3052. Gruz, P., Matsui, K., Sofuni, T., Nohmi, T. Mutat. Res. (1998) [Pubmed]
  12. The basis of the insensitivity of Salmonella typhimurium strain TA98/1,8-DNP6 to the mutagenic action of nitroarenes. McCoy, E.C., Anders, M., Rosenkranz, H.S. Mutat. Res. (1983) [Pubmed]
  13. Activation of K-ras and oncogenes other than ras family in rat fibrosarcomas induced by 1,8-dinitropyrene. Ochiai, M., Nagao, M., Tahira, T., Ishikawa, F., Hayashi, K., Ohgaki, H., Terada, M., Tsuchida, N., Sugimura, T. Cancer Lett. (1985) [Pubmed]
  14. Acetyl coenzyme A-dependent binding of carcinogenic and mutagenic dinitropyrenes to DNA. Djuríc, Z., Fifer, E.K., Beland, F.A. Carcinogenesis (1985) [Pubmed]
  15. Adsorption of a hydrophobic mutagen to dietary fiber from taro (Colocasia esculenta), an important food plant of the South Pacific. Ferguson, L.R., Roberton, A.M., McKenzie, R.J., Watson, M.E., Harris, P.J. Nutrition and cancer. (1992) [Pubmed]
  16. Erythrocyte-mediated toxification of 1,8-dinitropyrene. II. Covalent bind to erythrocyte-proteins. Belisario, M.A., Garofalo, A., Maturo, M., Avagnale, G., Sannolo, N., Malorni, A. Boll. Soc. Ital. Biol. Sper. (1995) [Pubmed]
  17. Dinitropyrene metabolism, DNA adduct formation, and DNA amplification in an SV40-transformed Chinese hamster embryo cell line. Neft, R.E., Roe, A.L., Smith, B.A., Beland, F.A. Mol. Carcinog. (1993) [Pubmed]
  18. A model system for studying the adsorption of a hydrophobic mutagen to dietary fibre. Roberton, A.M., Harris, P.J., Hollands, H.J., Ferguson, L.R. Mutat. Res. (1990) [Pubmed]
  19. DNA binding by 1-nitropyrene and dinitropyrenes in vitro and in vivo: effects of nitroreductase induction. Beland, F.A. Research report (Health Effects Institute) (1989) [Pubmed]
  20. Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. Yamazaki, H., Hatanaka, N., Kizu, R., Hayakawa, K., Shimada, N., Guengerich, F.P., Nakajima, M., Yokoi, T. Mutat. Res. (2000) [Pubmed]
  21. In vitro adsorption of a hydrophobic mutagen to gastrointestinal mucus glycoprotein (mucin) and dietary fibre. Ng, T.C., Ferguson, L.R., Harris, P.J., Watson, M.E., Roberton, A.M. Chem. Biol. Interact. (1992) [Pubmed]
  22. Purified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro. Hajos, A.K., Winston, G.W. J. Biochem. Toxicol. (1991) [Pubmed]
  23. Identification of 1,6- and 1,8-dinitropyrene isomers as major mutagens in organic extracts of soil from Osaka, Japan. Watanabe, T., Ishida, S., Minami, H., Kasai, T., Ogawa, S., Wakabayashi, K., Hirayama, T. Chem. Res. Toxicol. (1998) [Pubmed]
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