Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

vls - valois

Drosophila melanogaster

Synonyms: 38B.5, CG107278, CG10728, Dmel\CG10728, MEP50 homolog, ...

Anne, J. et al., Cavey, M. et al.

Anne, Mechler,

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High impact information on vls

Moreover vls is required for the synthesis and/or stability of Oskar and the localization of Tudor (Tud) in both the nuage and at the posterior pole of the oocyte [1].
Using the Capsuleen (Csul) methyltransferase as bait in the yeast two-hybrid system, we have identified a novel Drosophila protein containing multiple WD repeats and encoded by the valois (vsl) gene, which acts in pole plasm function [1].
We show that vls encodes a divergent WD domain protein and that the three available EMS-induced point mutations cause premature stop codons in the vls ORF [2].

References

Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuléen. Anne, J., Mechler, B.M. Development (2005) [Pubmed]
Drosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation. Cavey, M., Hijal, S., Zhang, X., Suter, B. Development (2005) [Pubmed]

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