The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

tud  -  tudor

Drosophila melanogaster

Synonyms: CG9450, Dmel\CG9450, Maternal protein tudor, TUD, Tud, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on tud

  • Developmental analysis of a newly isolated maternal effect grandchildless mutant, tudor (tud), in Drosophila melanogaster indicates that tud+ activity is required during oogenesis for the determination and/or formation of primordial germ cells (pole cells) and for normal embryonic abdominal segmentation [1].
  • Polytene chromosome staining, chromatin immunoprecipitation, direct messenger RNA analysis, and transient cotransfection assays identified the Drosophila gene tudor as containing a TRF1-responsive promoter [2].
  • Genetics has revealed three additional genes, staufen, vasa, and tudor, that are also essential for pole plasm formation [3].
  • Finally, we show that in the pole plasm, Oskar protein, like Vasa and Tudor, is a component of polar granules, the germ-line-specific RNP structures [3].
  • Taken together, these results indicate that the tud product is a novel protein required during oogenesis for establishment of a functional center of morphogenetic activity in the posterior tip of the Drosophila embryo [4].
 

Biological context of tud

  • Finally, we show that Tudor can be targeted to the nuage in the absence of Sm methylation by Capsul??en, indicating that Tudor localization and Sm methylation are separate processes [5].
  • Eleven chromosomal deficiencies and several rearrangements in the Pu-tud region of chromosome 2R have been generated and examined cytologically [6].
  • All new alleles fully complement tud for both lethal and grandchildless phenotypes [6].
  • Mutations in the tudor locus of Drosophila affect two distinct determinative processes in embryogenesis; segmentation of the abdomen and determination of the primordial germ cells [7].
  • Analysis of embryos of different maternal genotypes indicates that the average number of pole cells formed is correlated with the amount of tudor protein that accumulates in the germ plasm [7].
 

Anatomical context of tud

  • In particular, we show that the nuage and pole plasm localization of Tudor, an essential component for germ cell formation, are abolished in csul mutant germ cells [5].
  • During oogenesis, tud mRNA appears to be present in the oocyte precursor within the germarial cysts, and in stages 1-3 it accumulates within the developing oocyte [4].
  • Very little is known about the specific role of this organelle, but in Drosophila three nuage components have been identified, the Vasa, Tudor and Aubergine proteins [8].
 

Other interactions of tud

  • Homologues of Drosophila germ cell determinant genes such as vasa, nanos and tudor have recently been implicated in development of the male germline in mice [9].
  • Mst89B transcripts were present throughout spermatogenesis in germline-derived cells, consistent with northern analysis which showed that they were absent in the offspring of tudor flies that lack a germline [10].
  • Here we show that Tudor-SN (tudor staphylococcal nuclease)--a protein containing five staphylococcal/micrococcal nuclease domains and a tudor domain--is a component of the RISC enzyme in Caenorhabditis elegans, Drosophila and mammals [11].
  • There are significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains [12].

References

  1. tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster. Boswell, R.E., Mahowald, A.P. Cell (1985) [Pubmed]
  2. Promoter-selective properties of the TBP-related factor TRF1. Holmes, M.C., Tjian, R. Science (2000) [Pubmed]
  3. Oskar protein interaction with Vasa represents an essential step in polar granule assembly. Breitwieser, W., Markussen, F.H., Horstmann, H., Ephrussi, A. Genes Dev. (1996) [Pubmed]
  4. tudor, a posterior-group gene of Drosophila melanogaster, encodes a novel protein and an mRNA localized during mid-oogenesis. Golumbeski, G.S., Bardsley, A., Tax, F., Boswell, R.E. Genes Dev. (1991) [Pubmed]
  5. Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Anne, J., Ollo, R., Ephrussi, A., Mechler, B.M. Development (2007) [Pubmed]
  6. A cytogenetic analysis of the Punch-tudor region of chromosome 2R in Drosophila melanogaster. O'Donnell, J., Boswell, R., Reynolds, T., Mackay, W. Genetics (1989) [Pubmed]
  7. Distribution of tudor protein in the Drosophila embryo suggests separation of functions based on site of localization. Bardsley, A., McDonald, K., Boswell, R.E. Development (1993) [Pubmed]
  8. Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components. Snee, M.J., Macdonald, P.M. J. Cell. Sci. (2004) [Pubmed]
  9. Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Smith, J.M., Bowles, J., Wilson, M., Teasdale, R.D., Koopman, P. Gene Expr. Patterns (2004) [Pubmed]
  10. A testis-specifically expressed gene is embedded within a cluster of maternally expressed genes at 89B in Drosophila melanogaster. Stebbings, L., Grimes, B.R., Bownes, M. Dev. Genes Evol. (1998) [Pubmed]
  11. A micrococcal nuclease homologue in RNAi effector complexes. Caudy, A.A., Ketting, R.F., Hammond, S.M., Denli, A.M., Bathoorn, A.M., Tops, B.B., Silva, J.M., Myers, M.M., Hannon, G.J., Plasterk, R.H. Nature (2003) [Pubmed]
  12. Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2). Sathyamurthy, A., Allen, M.D., Murzin, A.G., Bycroft, M. J. Biol. Chem. (2003) [Pubmed]
 
WikiGenes - Universities