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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pomca  -  proopiomelanocortin a

Danio rerio

Synonyms: ACTH, MSH, SI:bZ36D5.1, SI:bZ36D5.4, SO:0000704, ...
 
 
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High impact information on pomca

  • Inhibition of steroidogenesis by mc2r knockdown induces up-regulation of pomc expression in the anterior domain of pituitary corticotrophs [1].
  • Accordingly, dex suppresses pomc in the anterior domain only, leading to impaired expression of steroidogenic genes commencing at 3 dpf and interrenal hypoplasia via reduced interrenal proliferation [1].
  • Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END) [2].
  • Sequence comparison of zebrafish POMC to sequences of various other vertebrate species reveals four regions that are highly conserved during the evolution of vertebrates-the N-terminal region, ACTH, beta-MSH, and beta-endorphin, whereas the connecting peptides show a much higher degree of variability [3].

References

  1. Pituitary-interrenal interaction in zebrafish interrenal organ development. To, T.T., Hahner, S., Nica, G., Rohr, K.B., Hammerschmidt, M., Winkler, C., Allolio, B. Mol. Endocrinol. (2007) [Pubmed]
  2. Identification of two proopiomelanocortin genes in zebrafish (Danio rerio). Gonzalez-Nunez, V., Gonzalez-Sarmiento, R., Rodríguez, R.E. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  3. The pro-opiomelanocortin gene of the zebrafish (Danio rerio). Hansen, I.A., To, T.T., Wortmann, S., Burmester, T., Winkler, C., Meyer, S.R., Neuner, C., Fassnacht, M., Allolio, B. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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