Gene Review:
Pomc - proopiomelanocortin
Rattus norvegicus
Synonyms:
Corticotropin-lipotropin, POMC, Pomc1, Pomc2, Pro-opiomelanocortin, ...
Jégou,
Boutelet,
Vaudry,
Broberger,
Landry,
Wong,
Walsh,
Hökfelt,
Baskin,
Breininger,
Schwartz,
Havel,
Hahn,
Sindelar,
Baskin,
Dallman,
Weigle,
Schwartz,
Jørgensen,
Knigge,
Kjaer,
Møller,
Warberg,
Watanobe,
Schiöth,
Izumi,
Fan,
Ellacott,
Halatchev,
Takahashi,
Yu,
Cone,
Makino,
Asaba,
Nishiyama,
Hashimoto,
Korner,
Wissig,
Kim,
Conwell,
Wardlaw,
- Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats. Li, G., Zhang, Y., Wilsey, J.T., Scarpace, P.J. Diabetologia (2005)
- Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Havel, P.J., Hahn, T.M., Sindelar, D.K., Baskin, D.G., Dallman, M.F., Weigle, D.S., Schwartz, M.W. Diabetes (2000)
- Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes. Raposinho, P.D., Castillo, E., d'Alleves, V., Broqua, P., Pralong, F.P., Aubert, M.L. Endocrinology (2000)
- Fasting-induced increases of arcuate NPY mRNA and plasma corticosterone are blunted in the rat experienced neonatal maternal separation. Kim, H.J., Lee, J.H., Choi, S.H., Lee, Y.S., Jahng, J.W. Neuropeptides (2005)
- Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Cheung, C.C., Clifton, D.K., Steiner, R.A. Endocrinology (1997)
- Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases. Lazure, C., Leduc, R., Seidah, N.G., Thibault, G., Genest, J., Chrétien, M. Nature (1984)
- Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei. Fremeau, R.T., Lundblad, J.R., Pritchett, D.B., Wilcox, J.N., Roberts, J.L. Science (1986)
- Characterization and localization of proopiomelanocortin messenger RNA in the adult rat testis. Pintar, J.E., Schachter, B.S., Herman, A.B., Durgerian, S., Krieger, D.T. Science (1984)
- Thyroid hormone-mediated regulation of corticotropin-releasing hormone messenger ribonucleic acid in the rat. Shi, Z.X., Levy, A., Lightman, S.L. Endocrinology (1994)
- Beta-endorphin inhibits hypoglycemia-induced gene expression of corticotropin-releasing factor in the rat hypothalamus. Suda, T., Sato, Y., Sumitomo, T., Nakano, Y., Tozawa, F., Iwai, I., Yamada, M., Demura, H. Endocrinology (1992)
- Plasma leptin and ghrelin in the neonatal rat: interaction of dexamethasone and hypoxia. Bruder, E.D., Jacobson, L., Raff, H. J. Endocrinol. (2005)
- D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase. Cote, T.E., Felder, R., Kebabian, J.W., Sekura, R.D., Reisine, T., Affolter, H.U. J. Biol. Chem. (1986)
- Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats. Koban, M., Le, W.W., Hoffman, G.E. Endocrinology (2006)
- A Pituitary Cell Type Coexpressing Messenger Ribonucleic Acid of Proopiomelanocortin and the Glycoprotein Hormone {alpha}-Subunit in Neonatal Rat and Chicken: Rapid Decline with Age and Reappearance in Vitro under Regulatory Pressure of Corticotropin-Releasing Hormone in the Rat. Pals, K., Boussemaere, M., Swinnen, E., Vankelecom, H., Denef, C. Endocrinology (2006)
- Diurnal changes in hypothalamic neuropeptide and SOCS-3 expression: effects of lactation and relationship with serum leptin and food intake. Denis, R.G., Bing, C., Brocklehurst, S., Harrold, J.A., Vernon, R.G., Williams, G. J. Endocrinol. (2004)
- Regulation of CRF, POMC and MC4R gene expression after electrical foot shock stress in the rat amygdala and hypothalamus. Yamano, Y., Yoshioka, M., Toda, Y., Oshida, Y., Chaki, S., Hamamoto, K., Morishima, I. J. Vet. Med. Sci. (2004)
- Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Fan, W., Ellacott, K.L., Halatchev, I.G., Takahashi, K., Yu, P., Cone, R.D. Nat. Neurosci. (2004)
- Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Elias, C.F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R.S., Bjorbaek, C., Flier, J.S., Saper, C.B., Elmquist, J.K. Neuron (1999)
- gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Janoschek, R., Plum, L., Koch, L., Münzberg, H., Diano, S., Shanabrough, M., Müller, W., Horvath, T.L., Brüning, J.C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Savontaus, E., Conwell, I.M., Wardlaw, S.L. Brain Res. (2002)
- Stress responsiveness of hypothalamic corticotrophin-releasing factor and pituitary pro-opiomelanocortin mRNAs following high-dose glucocorticoid treatment and withdrawal in the rat. Harbuz, M.S., Nicholson, S.A., Gillham, B., Lightman, S.L. J. Endocrinol. (1990)
- Interaction between glucocorticoids and corticotropin releasing hormone (CRH) in the regulation of the pituitary CRH receptor in vivo in the rat. Ochedalski, T., Rabadan-Diehl, C., Aguilera, G. J. Neuroendocrinol. (1998)
- Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Drouin, J., Trifiro, M.A., Plante, R.K., Nemer, M., Eriksson, P., Wrange, O. Mol. Cell. Biol. (1989)
- Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. Jørgensen, H., Knigge, U., Kjaer, A., Møller, M., Warberg, J. J. Neuroendocrinol. (2002)
- Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Broberger, C., Landry, M., Wong, H., Walsh, J.N., Hökfelt, T. Neuroendocrinology (1997)
- Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats. Watanobe, H., Schiöth, H.B., Izumi, J. J. Neurochem. (2003)
- Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleus. Jégou, S., Boutelet, I., Vaudry, H. J. Neuroendocrinol. (2000)
- Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Baskin, D.G., Breininger, J.F., Schwartz, M.W. Diabetes (1999)
- Young Adult-Specific Hyperphagia in Diabetic Goto-Kakizaki Rats is Associated with Leptin Resistance and Elevation of Neuropeptide Y mRNA in the Arcuate Nucleus. Maekawa, F., Fujiwara, K., Kohno, D., Kuramochi, M., Kurita, H., Yada, T. J. Neuroendocrinol. (2006)
- Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression. Korner, J., Wissig, S., Kim, A., Conwell, I.M., Wardlaw, S.L. J. Neuroendocrinol. (2003)
- Evidence for daily rhythms of the expression of proopiomelanocortin, interleukin-1-beta and interleukin-6 in adenopituitaries of male long-evans rats: effect of adjuvant arthritis. Seres, J., Herichová, I., Roman, O., Bornstein, S., Jurcovicová, J. Neuroimmunomodulation (2004)
- Decreased type 2 corticotropin-releasing hormone receptor mRNA expression in the ventromedial hypothalamus during repeated immobilization stress. Makino, S., Asaba, K., Nishiyama, M., Hashimoto, K. Neuroendocrinology (1999)