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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hey  -  Hairy/E(spl)-related with YRPW motif

Drosophila melanogaster

Synonyms: CG11194, Dmel\CG11194, Hairy/enhancer-of-split related with YRPW motif protein, Hesr-1, bHLHe44, ...
 
 
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High impact information on Hey

  • Hairy-related transcription factor (HRT/Hey) genes encode a novel subfamily of basic helix-loop-helix (bHLH) transcription factors related to the Drosophila hairy and Enhancer-of-split (E(spl)) and the mammalian HES proteins that function as downstream mediators of Notch signaling [1].
  • While hairy/E(spl) proteins are characterized by an invariant proline residue in the basic domain and a carboxyterminal groucho-binding WRPW motif, our genes encode a carboxyterminal KPYRPWG sequence and were thus designated as Hey genes (Hairy/E(spl)-related with YRPW motif) [2].
  • Furthermore, they bear a unique C-terminal TE(I/V)GAF motif and the characteristic proline is changed in all Hey family members to glycine [2].

References

  1. Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse. Van Wayenbergh, R., Taelman, V., Pichon, B., Fischer, A., Kricha, S., Gessler, M., Christophe, D., Bellefroid, E.J. Dev. Dyn. (2003) [Pubmed]
  2. Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Leimeister, C., Externbrink, A., Klamt, B., Gessler, M. Mech. Dev. (1999) [Pubmed]
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