Gene Review:
E(spl)m8-HLH - Enhancer of split m8, helix-loop-helix
Drosophila melanogaster
Synonyms:
CG8365, Dmel\CG8365, E(Spl), E(spl), E(spl) m8, ...
- The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Lecourtois, M., Schweisguth, F. Genes Dev. (1995)
- An eh1-like motif in odd-skipped mediates recruitment of Groucho and repression in vivo. Goldstein, R.E., Cook, O., Dinur, T., Pisanté, A., Karandikar, U.C., Bidwai, A., Paroush, Z. Mol. Cell. Biol. (2005)
- The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Fisher, A.L., Ohsako, S., Caudy, M. Mol. Cell. Biol. (1996)
- Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Escudero, L.M., Wei, S.Y., Chiu, W.H., Modolell, J., Hsu, J.C. Development (2003)
- Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for notch activity in wing margin establishment in Drosophila. Ligoxygakis, P., Bray, S.J., Apidianakis, Y., Delidakis, C. Development (1999)
- Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. Klämbt, C., Knust, E., Tietze, K., Campos-Ortega, J.A. EMBO J. (1989)
- Drosophila melanogaster casein kinase II interacts with and phosphorylates the basic helix-loop-helix proteins m5, m7, and m8 derived from the Enhancer of split complex. Trott, R.L., Kalive, M., Paroush, Z., Bidwai, A.P. J. Biol. Chem. (2001)
- Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. Nishimura, M., Isaka, F., Ishibashi, M., Tomita, K., Tsuda, H., Nakanishi, S., Kageyama, R. Genomics (1998)
- The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Lai, E.C., Burks, C., Posakony, J.W. Development (1998)
- Identification and characterization of human HES2, HES3, and HES5 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004)
- Interactions among the bHLH domains of the proteins encoded by the Enhancer of split and achaete-scute gene complexes of Drosophila. Gigliani, F., Longo, F., Gaddini, L., Battaglia, P.A. Mol. Gen. Genet. (1996)
- Inducible RNA interference uncovers the Drosophila protein Bx42 as an essential nuclear cofactor involved in Notch signal transduction. Negeri, D., Eggert, H., Gienapp, R., Saumweber, H. Mech. Dev. (2002)
- Drosophila CK2 regulates eye morphogenesis via phosphorylation of E(spl)M8. Karandikar, U.C., Trott, R.L., Yin, J., Bishop, C.P., Bidwai, A.P. Mech. Dev. (2004)
- Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye. Li, Y., Baker, N.E. Curr. Biol. (2001)
- Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. Koop, K.E., MacDonald, L.M., Lobe, C.G. Mech. Dev. (1996)
- Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. Akazawa, C., Sasai, Y., Nakanishi, S., Kageyama, R. J. Biol. Chem. (1992)