Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Map60 - Microtubule-associated protein 60

Drosophila melanogaster

Synonyms: CG1825, CP-60, CP60, Cp60, DMAP-60, ...

Raff, J.W. et al., Kellogg, D.R. et al.

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High impact information on Map60

Here we show that gamma-tubulin is a component of a previously isolated complex of Drosophila proteins that contains at least two centrosomal microtubule-associated proteins called DMAP190 and DMAP60 [1].
We show that gamma-tubulin binds to a microtubule column as part of a complex, and a substantial fraction of this gamma-tubulin is tightly associated with DMAP60 [1].
Like DMAP190 and DMAP60, the gamma-tubulin in extracts of early Drosophila embryos binds to microtubules, although this binding may be indirect [1].
Like DMAP190, DMAP60 interacts with microtubules and is localized to the centrosome, and the two proteins associate as part of a multiprotein complex [2].

Other interactions of Map60

In a previous study, we used affinity chromatography to identify proteins that interact with DMAP190, and identified a 60-kDa protein that we named DMAP60 (Kellogg and Alberts, 1992) [2].

Analytical, diagnostic and therapeutic context of Map60

As judged by in situ hybridization, the gene for DMAP60 maps to chromosomal region 46A [2].

References

Drosophila gamma-tubulin is part of a complex containing two previously identified centrosomal MAPs. Raff, J.W., Kellogg, D.R., Alberts, B.M. J. Cell Biol. (1993) [Pubmed]
CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner. Kellogg, D.R., Oegema, K., Raff, J., Schneider, K., Alberts, B.M. Mol. Biol. Cell (1995) [Pubmed]

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