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Gene Review

Cp190  -  Centrosomal protein 190kD

Drosophila melanogaster

Synonyms: AbS1-4, Bx-63, Bx63, CEN190, CG6384, ...
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High impact information on Cp190

  • Rm62 interacts physically with the DNA-binding insulator protein CP190 in an RNA-dependent manner [1].
  • The centrosome associated protein CP190 is partially lost from the spindle poles in dd4 cells supporting a weak interaction with gamma-tubulin, and the displaced protein accumulates in the vicinity of chromosomes [2].
  • The function of the centrosome is not affected in CP190 mutants whereas gypsy insulator activity is impaired [3].
  • CP190 associates physically with both Su(Hw) and Mod(mdg4)2.2 and colocalizes with both proteins on polytene chromosomes [3].
  • A genetic screen for dominant enhancers of the mod(mdg4) phenotype identified the Centrosomal Protein 190 (CP190) as an essential constituent of the gypsy insulator [3].

Biological context of Cp190


Anatomical context of Cp190


Associations of Cp190 with chemical compounds

  • To characterize the regions of CP190 responsible for its dynamic behavior, we injected rhodamine-labeled fusion proteins spanning most of CP190 into early Drosophila embryos, where their localizations were characterized using time-lapse fluorescence confocal microscopy [5].
  • Centrosomal localization of the CP190 antigen was prevented by incubation of the permeabilized zygote in 20 mM EDTA [11].
  • The analysis of chilled and nocodazole-treated embryos suggests that the localization of the midzone Bx63 antigen is dependent on non-kinetochore microtubules [12].

Other interactions of Cp190

  • In a previous study, we used affinity chromatography to identify proteins that interact with DMAP190, and identified a 60-kDa protein that we named DMAP60 (Kellogg and Alberts, 1992) [4].
  • The CP60 and CP190 can be removed from this extract without effect, whereas removing the gamma-tubulin destroys the complementing activity [13].
  • Thus, CP190 has distinct nuclear and centrosomal functions, and it provides a crucial link between the centrosome/MT and actin/myosin cytoskeletal systems in early embryos [7].

Analytical, diagnostic and therapeutic context of Cp190


  1. RNA interference machinery influences the nuclear organization of a chromatin insulator. Lei, E.P., Corces, V.G. Nat. Genet. (2006) [Pubmed]
  2. Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization. Barbosa, V., Yamamoto, R.R., Henderson, D.S., Glover, D.M. Genes Dev. (2000) [Pubmed]
  3. The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Pai, C.Y., Lei, E.P., Ghosh, D., Corces, V.G. Mol. Cell (2004) [Pubmed]
  4. CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner. Kellogg, D.R., Oegema, K., Raff, J., Schneider, K., Alberts, B.M. Mol. Biol. Cell (1995) [Pubmed]
  5. The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains. Oegema, K., Whitfield, W.G., Alberts, B. J. Cell Biol. (1995) [Pubmed]
  6. Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190. Oegema, K., Marshall, W.F., Sedat, J.W., Alberts, B.M. J. Cell. Sci. (1997) [Pubmed]
  7. The centrosomal protein CP190 regulates myosin function during early Drosophila development. Chodagam, S., Royou, A., Whitfield, W., Karess, R., Raff, J.W. Curr. Biol. (2005) [Pubmed]
  8. The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila. Megraw, T.L., Li, K., Kao, L.R., Kaufman, T.C. Development (1999) [Pubmed]
  9. Elongation of centriolar microtubule triplets contributes to the formation of the mitotic spindle in gamma-tubulin-depleted cells. Raynaud-Messina, B., Mazzolini, L., Moisand, A., Cirinesi, A.M., Wright, M. J. Cell. Sci. (2004) [Pubmed]
  10. The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes. Whitfield, W.G., Chaplin, M.A., Oegema, K., Parry, H., Glover, D.M. J. Cell. Sci. (1995) [Pubmed]
  11. Assembly of the zygotic centrosome in the fertilized Drosophila egg. Riparbelli, M.G., Whitfield, W.G., Dallai, R., Callaini, G. Mech. Dev. (1997) [Pubmed]
  12. A centrosome-associated antibody from Drosophila melanogaster reveals a new microtubule-dependent structure in the equatorial zone of Parascaris univalens embryos. Jiménez, M., Goday, C. J. Cell. Sci. (1993) [Pubmed]
  13. Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. Moritz, M., Zheng, Y., Alberts, B.M., Oegema, K. J. Cell Biol. (1998) [Pubmed]
  14. Cloning of a gene encoding an antigen associated with the centrosome in Drosophila. Whitfield, W.G., Millar, S.E., Saumweber, H., Frasch, M., Glover, D.M. J. Cell. Sci. (1988) [Pubmed]
  15. The response of the centrosome to heat shock and related stresses in a Drosophila cell line. Debec, A., Courgeon, A.M., Maingourd, M., Maisonhaute, C. J. Cell. Sci. (1990) [Pubmed]
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