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Gene Review

gammaTub23C  -  gamma-Tubulin at 23C

Drosophila melanogaster

Synonyms: CG 3157, CG3157, D.m.GAMMA-23C, Dmel\CG3157, GAMMA23C, ...
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High impact information on gammaTub23C


Biological context of gammaTub23C

  • Gamma-tub37CD is constantly detected at the centrosome and absent in the mitotic spindle, while gamma-tub23C is extensively recruited to the centrosome during mitosis and relocalizes in the mitotic spindle [4].
  • To gain a better understanding of their molecular nature, we have studied the centrosomal component gamma-tubulin during Drosophila oogenesis [5].
  • With the exception of gamma-tubulin, Dgp71WD is the only gammaTuRC component identified to date that does not contain the grip motifs, which are signature sequences conserved in gammaTuRC components [6].
  • The unusual disk- or ring-shaped central spindle pole body forms de novo in the center of the elongated meiosis I spindle, followed by formation of the central spindle poles. gamma-Tubulin transiently localizes to the central spindle pole body, implying that the body acts as a microtubule nucleating center for assembly of the central poles [7].
  • This conclusion is based on the identification and phenotypic characterization of a mutant allele of the gamma-tubulin gene located at region 23C of the polytene chromosome map [8].

Anatomical context of gammaTub23C

  • The gamma-tubulin ring complex (gammaTuRC) is important for microtubule nucleation from the centrosome [9].
  • The gamma-tubulin ring complex (gammaTuRC) forms an essential template for microtubule nucleation in animal cells [10].
  • Using specific nucleotidic and immunological probes, we have demonstrated that the two divergent Drosophila gamma-tubulins, gamma-tub23C and gamma-tub37CD, are expressed in cultured cells [4].
  • Gamma-tub23C is present in the soluble gamma-tubulin small complexes (10S) and gamma-tubulin big complexes (35S) and is loosely associated to the cytoskeleton [4].
  • The combination of loss-of-function mutant alleles for the two gamma-tubulin genes leads to mitotic defects in female germ cells, resulting in agametic ovaries [5].

Associations of gammaTub23C with chemical compounds

  • Coexpression of any of these grip motif-containing proteins with gamma-tubulin promotes gamma-tubulin binding to guanine nucleotide [6].

Other interactions of gammaTub23C


Analytical, diagnostic and therapeutic context of gammaTub23C

  • Yet, immunofluorescence revealed that spindles in larval brains of urchin mutants in Drosophila were frequently monastral but bipolar; the astral pole contained a centrosome while the opposing anastral pole showed neither gamma tubulin nor a radial array of astral microtubules [15].


  1. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. Zheng, Y., Jung, M.K., Oakley, B.R. Cell (1991) [Pubmed]
  2. Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers. do Carmo Avides, M., Glover, D.M. Science (1999) [Pubmed]
  3. Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. Terada, Y., Uetake, Y., Kuriyama, R. J. Cell Biol. (2003) [Pubmed]
  4. Differential properties of the two Drosophila gamma-tubulin isotypes. Raynaud-Messina, B., Debec, A., Tollon, Y., Garès, M., Wright, M. Eur. J. Cell Biol. (2001) [Pubmed]
  5. gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila. Tavosanis, G., Gonzalez, C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Characterization of a new gammaTuRC subunit with WD repeats. Gunawardane, R.N., Martin, O.C., Zheng, Y. Mol. Biol. Cell (2003) [Pubmed]
  7. Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes. Endow, S.A., Komma, D.J. J. Cell. Sci. (1998) [Pubmed]
  8. Gamma-tubulin is required for the structure and function of the microtubule organizing centre in Drosophila neuroblasts. Sunkel, C.E., Gomes, R., Sampaio, P., Perdigão, J., González, C. EMBO J. (1995) [Pubmed]
  9. Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits. Gunawardane, R.N., Martin, O.C., Cao, K., Zhang, L., Dej, K., Iwamatsu, A., Zheng, Y. J. Cell Biol. (2000) [Pubmed]
  10. The {gamma}TuRC components Grip75 and Grip128 have an essential microtubule-anchoring function in the Drosophila germline. Vogt, N., Koch, I., Schwarz, H., Schnorrer, F., N??sslein-Volhard, C. Development (2006) [Pubmed]
  11. Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. Oegema, K., Wiese, C., Martin, O.C., Milligan, R.A., Iwamatsu, A., Mitchison, T.J., Zheng, Y. J. Cell Biol. (1999) [Pubmed]
  12. Elongation of centriolar microtubule triplets contributes to the formation of the mitotic spindle in gamma-tubulin-depleted cells. Raynaud-Messina, B., Mazzolini, L., Moisand, A., Cirinesi, A.M., Wright, M. J. Cell. Sci. (2004) [Pubmed]
  13. Miranda, a protein involved in neuroblast asymmetric division, is associated with embryonic centrosomes of Drosophila melanogaster. Mollinari, C., Lange, B., González, C. Biol. Cell (2002) [Pubmed]
  14. Drosophila gamma-tubulin is part of a complex containing two previously identified centrosomal MAPs. Raff, J.W., Kellogg, D.R., Alberts, B.M. J. Cell Biol. (1993) [Pubmed]
  15. Monastral bipolar spindles: implications for dynamic centrosome organization. Wilson, P.G., Fuller, M.T., Borisy, G.G. J. Cell. Sci. (1997) [Pubmed]
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