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Gene Review

Prosalpha7  -  Proteasome alpha7 subunit

Drosophila melanogaster

Synonyms: 1519, 20S proteasome subunit alpha-7, Alpha-7, Alpha7, CG1519, ...
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High impact information on Prosalpha7

  • The anthelmintic nicotinic agonist levamisole is unable to activate the Ce21 and alpha7 receptors, but efficiently antagonises their responses to ACh [1].
  • Imidacloprid and nitenpyram were partial agonists and a nitromethylene analog of imidacloprid (CH-IMI) was a full agonist of the alpha7 receptor, whereas their agonist actions on the alpha4beta2 receptor were very weak, contrasting with full agonist actions of DN-IMI, a desnitro derivative of imidacloprid [2].
  • The principal mammalian brain nicotinic acetylcholine receptors (nAChRs) are the alpha-bungarotoxin (alpha-BGT)-insensitive alpha 4 beta 2 and the alpha-BGT-sensitive alpha 7 subtypes assayed with radiolabeled nicotinoids and alpha-BGT, respectively [3].


  1. Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans. Ballivet, M., Alliod, C., Bertrand, S., Bertrand, D. J. Mol. Biol. (1996) [Pubmed]
  2. Diverse actions of neonicotinoids on chicken alpha7, alpha4beta2 and Drosophila-chicken SADbeta2 and ALSbeta2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Ihara, M., Matsuda, K., Otake, M., Kuwamura, M., Shimomura, M., Komai, K., Akamatsu, M., Raymond, V., Sattelle, D.B. Neuropharmacology (2003) [Pubmed]
  3. Drosophila nicotinic receptors: evidence for imidacloprid insecticide and alpha-bungarotoxin binding to distinct sites. Zhang, N., Tomizawa, M., Casida, J.E. Neurosci. Lett. (2004) [Pubmed]
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