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Gene Review

PRE10  -  proteasome core particle subunit alpha 7

Saccharomyces cerevisiae S288c

Synonyms: Macropain subunit C1, Multicatalytic endopeptidase complex subunit C1, O6650, PRC1, PRS1, ...
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High impact information on PRE10

  • When PRS1 is lacking, the basal level of phosphorylation of Slt2 is increased [1].
  • However, the fact that disruption of this gene causes the most dramatic decrease in cell growth rate and enzyme activity suggests that Prs1p may have a key structural or regulatory role in the production of PRPP in the cell [2].
  • PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae [2].
  • Using Western blot analysis with antisera raised against peptides derived from the non-homology region (NHR) and the N-terminal half of the PRS1 gene product it has been shown that the NHR is not removed by protein splicing [2].
  • Physical mapping by hybridization to intact S. cerevisiae chromosomal DNA showed that the PRS3 gene is located on chromosome II, unlike two other subunit genes, PRS1 and PRS2, which are located on chromosomes XV and VII, respectively [3].

Biological context of PRE10

  • A peptide reproducing the long acidic C-terminal tail of alpha 7/PRS1, where consensus CK2 phosphorylation sites are located, was also phosphorylated by the CK2 holoenzyme in a polylysine-dependent manner, suggesting that this region contains structural features responsible for this particular behavior [4].

Other interactions of PRE10


Analytical, diagnostic and therapeutic context of PRE10


  1. Impaired PRPP-synthesizing capacity compromises cell integrity signalling in Saccharomyces cerevisiae. Wang, K., Vavassori, S., Schweizer, L.M., Schweizer, M. Microbiology (Reading, Engl.) (2004) [Pubmed]
  2. PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Carter, A.T., Beiche, F., Hove-Jensen, B., Narbad, A., Barker, P.J., Schweizer, L.M., Schweizer, M. Mol. Gen. Genet. (1997) [Pubmed]
  3. PRS3 encoding an essential subunit of yeast proteasomes homologous to mammalian proteasome subunit C5. Lee, D.H., Tanaka, K., Tamura, T., Chung, C.H., Ichihara, A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  4. In vivo and in vitro phosphorylation of the alpha 7/PRS1 subunit of Saccharomyces cerevisiae 20 S proteasome: in vitro phosphorylation by protein kinase CK2 is absolutely dependent on polylysine. Pardo, P.S., Murray, P.F., Walz, K., Franco, L., Passeron, S. Arch. Biochem. Biophys. (1998) [Pubmed]
  5. Molecular cloning of the yeast proteasome PRS2 gene identical to the suppressor gene scl1+. Lee, D.H., Tamura, T., Chung, C.H., Tanaka, K., Ichihara, A. Biochem. Int. (1991) [Pubmed]
  6. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit. Zaiss, D., Belote, J.M. Gene (1997) [Pubmed]
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