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Gene Review:

Tyrobp - Tyro protein tyrosine kinase binding protein

Rattus norvegicus

Synonyms: DNAX-activation protein 12, Dap12, TYRO protein tyrosine kinase-binding protein

Mason, L.H. et al.

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High impact information on Tyrobp

However, Dap-12 is not phosphorylated when Ly-49D+ NK cells coexpress the inhibitory receptor, Ly-49G [1].
Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion [1].
Ly-49D activation is mediated by the immunoreceptor tyrosine-based activation motif-containing signaling moiety Dap-12 [1].
Importantly, we are able to demonstrate for the first time that effector/target cell interactions using Ly-49D+ NK cells and H-2Dd targets result in the rapid phosphorylation of Dap-12 [1].

References

Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion. Mason, L.H., Willette-Brown, J., Mason, A.T., McVicar, D., Ortaldo, J.R. J. Immunol. (2000) [Pubmed]

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