Disease relevance of Procr

• Consistent with the idea that the responses were mediated by thrombin, thrombin infusion (5 U/kg of body weight for 3 hours) resulted in an approximately 2-fold increase in EPCR mRNA and soluble EPCR [1].

High impact information on Procr

• The endothelial cell protein C receptor (EPCR) facilitates protein C activation by the thrombin-thrombomodulin complex [1].
• Incubation of rat endothelial cells with thrombin or murine protease-activated receptor 1 agonist peptide resulted in a 2-fold increase in EPCR mRNA [1].

Analytical, diagnostic and therapeutic context of Procr

• Rather than EPCR mRNA levels falling in response to endotoxin, as predicted from cell-culture experiments, they rose approximately 3-fold 6 hours after exposure to endotoxin before returning toward baseline levels at 24 hours after exposure [1].

References