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Gene Review

Procr  -  protein C receptor, endothelial

Rattus norvegicus

Synonyms: APC receptor, Activated protein C receptor, Endothelial cell protein C receptor, Endothelial protein C receptor
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Disease relevance of Procr

  • Consistent with the idea that the responses were mediated by thrombin, thrombin infusion (5 U/kg of body weight for 3 hours) resulted in an approximately 2-fold increase in EPCR mRNA and soluble EPCR [1].

High impact information on Procr


Analytical, diagnostic and therapeutic context of Procr

  • Rather than EPCR mRNA levels falling in response to endotoxin, as predicted from cell-culture experiments, they rose approximately 3-fold 6 hours after exposure to endotoxin before returning toward baseline levels at 24 hours after exposure [1].


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