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Gene Review:

ardA - antirestriction protein

Escherichia coli

Nekrasov, S.V. et al., Nader, W.F. et al.

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Disease relevance of ardA

Structure of Physarum actin gene locus ardA: a nonpalindromic sequence causes inviability of phage lambda and recA-independent deletions [1].

High impact information on ardA

In addition, a lot of the putative ardA genes encoded by plasmids and bacterial chromosomes are found as a result of sequencing of complete genomic sequences, suggesting that ArdA proteins and type I R-M systems that seem to be widespread among bacteria may be involved in the regulation of gene transfer among bacterial genomes [2].
Here, the mechanism of antirestriction action of ArdA encoded by IncI plasmid ColIb-P9 has been investigated in comparison with that of well-studied T7 phage-encoded antirestriction protein Ocr using the mutational analysis, retardation assay and His-tag affinity chromatography [2].
Within the ardA gene we have located a 360-bp fragment which comprises exon V and parts of its flanking introns [1].

References

Structure of Physarum actin gene locus ardA: a nonpalindromic sequence causes inviability of phage lambda and recA-independent deletions. Nader, W.F., Isenberg, G., Sauer, H.W. Gene (1986) [Pubmed]
Plasmid-encoded Antirestriction Protein ArdA Can Discriminate between Type I Methyltransferase and Complete Restriction-Modification System. Nekrasov, S.V., Agafonova, O.V., Belogurova, N.G., Delver, E.P., Belogurov, A.A. J. Mol. Biol. (2007) [Pubmed]

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