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Gene Review

Tb11.01.0360  -  RAD51 protein

Trypanosoma brucei brucei TREU927

 
 
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High impact information on Tb11.01.0360

  • We show that the RAD51-independent pathway is capable of recombining DNA substrates with very short lengths of sequence homology and in some cases aberrant recombination reactions can be detected using such microhomologies [1].
  • Much of VSG switching appears to rely on a widely conserved DNA repair pathway called homologous recombination, driven by RAD51 [2].
  • Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation [2].

References

  1. Two pathways of homologous recombination in Trypanosoma brucei. Conway, C., Proudfoot, C., Burton, P., Barry, J.D., McCulloch, R. Mol. Microbiol. (2002) [Pubmed]
  2. Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation. Proudfoot, C., McCulloch, R. Nucleic Acids Res. (2005) [Pubmed]
 
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