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Gene Review:

ISLR - immunoglobulin superfamily containing...

Homo sapiens

Synonyms: HsT17563, Immunoglobulin superfamily containing leucine-rich repeat protein, UNQ189/PRO215

Nagasawa, A. et al., Nagasawa, A. et al.

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High impact information on ISLR

Sequence analysis of the ISLR gene in five BBS4 patients, however, showed no mutations, although a few polymorphic changes were detected [1].
Radiation hybrid mapping linked the ISLR gene to AFM248yh1, which is in the critical region of Bardet-Biedl syndrome type 4 (BBS4) on chromosome 15 [1].
Genomic sequencing of the ISLR gene revealed that these two types of transcripts, ISLR-1 and ISLR-2, originated from the same gene but are composed of different first exons [1].
The ISLR gene was mapped on human chromosome 15q23-q24 by fluorescence in situ hybridization [2].
These domains are known to be important for protein-protein interaction or cell adhesion, and therefore it is possible that the novel protein ISLR may also interact with other proteins or cells [2].

References

Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression. Nagasawa, A., Kudoh, J., Noda, S., Mashima, Y., Wright, A., Oguchi, Y., Shimizu, N. Genomics (1999) [Pubmed]
Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). Nagasawa, A., Kubota, R., Imamura, Y., Nagamine, K., Wang, Y., Asakawa, S., Kudoh, J., Minoshima, S., Mashima, Y., Oguchi, Y., Shimizu, N. Genomics (1997) [Pubmed]

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ISLR	Bos taurus
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ISLR	Gallus gallus
ISLR	Macaca mulatta
Islr	Mus musculus
ISLR	Pan troglodytes
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