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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mrj  -  CG8448 gene product from transcript CG8448-RD

Drosophila melanogaster

Synonyms: CG8448, Dmel\CG8448, MRJ, dMRJ, dmrj
 
 
 
 
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Disease relevance of mrj

  • In the retina and other neurons, transgenic dMRJ suppressed polyQ toxicity and colocalized with its inclusions [1].
 

High impact information on mrj

  • In the photoreceptors, expression of another suppressor with a J domain, dHDJ1, but not dMRJ, prior to expression of expanded polyQs dramatically promoted cytoplasmic aggregation [1].

References

  1. A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation. Fayazi, Z., Ghosh, S., Marion, S., Bao, X., Shero, M., Kazemi-Esfarjani, P. Neurobiol. Dis. (2006) [Pubmed]
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