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Gene Review

DnaJ-1  -  DnaJ-like-1

Drosophila melanogaster

Synonyms: CG10578, DNAJ-1, DNAJ1, DROJ1, Dmel\CG10578, ...
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Disease relevance of DnaJ-1


High impact information on DnaJ-1

  • The DnaJ-like cysteine string protein and exocytotic neurotransmitter release [5].
  • Overexpression of DROJ1 in Drosophila SL2 cells delays the onset of the heat shock response [6].
  • Moreover, RNA interference involving transfection of SL2 cells with double-stranded droj1 RNA depletes the endogenous level of DROJ1 protein, leading to constitutive activation of endogenous heat shock genes [6].
  • Tid1, a DnaJ cochaperone protein, is the mammalian homologue of the Drosophila tumor suppressor Tid56 whose antitumor function is most likely mediated through its capacity to regulate cell differentiation in imaginal discs [7].
  • In the photoreceptors, expression of another suppressor with a J domain, dHDJ1, but not dMRJ, prior to expression of expanded polyQs dramatically promoted cytoplasmic aggregation [8].

Biological context of DnaJ-1


Anatomical context of DnaJ-1

  • We recovered cell lines containing between three and about 50 copies of both pCV31gpt and pMH10A, a cloned 87 A7 hsp70 heat-shock locus that encodes a mutant 40,000-dalton heat-shock protein (hsp40) [10].

Other interactions of DnaJ-1


Analytical, diagnostic and therapeutic context of DnaJ-1


  1. Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteins. Sohn, S.Y., Kim, S.B., Kim, J., Ahn, B.Y. J. Gen. Virol. (2006) [Pubmed]
  2. Expression of the Caulobacter heat shock gene dnaK is developmentally controlled during growth at normal temperatures. Gomes, S.L., Gober, J.W., Shapiro, L. J. Bacteriol. (1990) [Pubmed]
  3. Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine. Karpuj, M.V., Becher, M.W., Springer, J.E., Chabas, D., Youssef, S., Pedotti, R., Mitchell, D., Steinman, L. Nat. Med. (2002) [Pubmed]
  4. Understanding human cancer using Drosophila: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l2Tid, is a novel molecular partner of patched related to skin cancer. Canamasas, I., Debes, A., Natali, P.G., Kurzik-Dumke, U. J. Biol. Chem. (2003) [Pubmed]
  5. The DnaJ-like cysteine string protein and exocytotic neurotransmitter release. Buchner, E., Gundersen, C.B. Trends Neurosci. (1997) [Pubmed]
  6. Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1. Marchler, G., Wu, C. EMBO J. (2001) [Pubmed]
  7. Tid1 is required for T cell transition from double-negative 3 to double-positive stages. Lo, J.F., Zhou, H., Fearns, C., Reisfeld, R.A., Yang, Y., Lee, J.D. J. Immunol. (2005) [Pubmed]
  8. A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation. Fayazi, Z., Ghosh, S., Marion, S., Bao, X., Shero, M., Kazemi-Esfarjani, P. Neurobiol. Dis. (2006) [Pubmed]
  9. Thermoprotection of synaptic transmission in a Drosophila heat shock factor mutant is accompanied by increased expression of Hsp83 and DnaJ-1. Neal, S.J., Karunanithi, S., Best, A., So, A.K., Tanguay, R.M., Atwood, H.L., Westwood, J.T. Physiol. Genomics (2006) [Pubmed]
  10. Integration of Drosophila heat-shock genes transfected into cultured Drosophila melanogaster cells. Burke, J.F., Pinchin, S.M., Ish-Horowicz, D., Sinclair, J.H., Sang, J.H. Somat. Cell Mol. Genet. (1984) [Pubmed]
  11. Mitochondrial localization and temporal expression of the Drosophila melanogaster DnaJ homologous tumor suppressor Tid50. Kurzik-Dumke, U., Debes, A., Kaymer, M., Dienes, P. Cell Stress Chaperones (1998) [Pubmed]
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