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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NCR1  -  natural cytotoxicity triggering receptor 1

Bos taurus

 
 
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Disease relevance of NCR1

 

High impact information on NCR1

  • The activating receptor NKp46 was involved in cytotoxicity against fibroblasts but could not explain the increased cytotoxicity against infected targets [2].
  • The production of IFN-gamma by NK cells in whole blood in response to ESAT-6 and MPP14 was demonstrated using intracellular staining together with surface labeling for the NK cell-specific receptor, NKp46, or CD3 [3].
  • Recently, a monoclonal antibody directed against bovine NKp46, a receptor that is expressed exclusively on NK cells, was developed [4].

References

  1. Bovine natural killer cells restrict the replication of Mycobacterium bovis in bovine macrophages and enhance IL-12 release by infected macrophages. Denis, M., Keen, D.L., Parlane, N.A., Storset, A.K., Buddle, B.M. Tuberculosis (Edinburgh, Scotland) (2007) [Pubmed]
  2. The protozoan Neospora caninum directly triggers bovine NK cells to produce gamma interferon and to kill infected fibroblasts. Boysen, P., Klevar, S., Olsen, I., Storset, A.K. Infect. Immun. (2006) [Pubmed]
  3. Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70. Olsen, I., Boysen, P., Kulberg, S., Hope, J.C., Jungersen, G., Storset, A.K. Infect. Immun. (2005) [Pubmed]
  4. Reference values for relative numbers of natural killer cells in cattle blood. Kulberg, S., Boysen, P., Storset, A.K. Dev. Comp. Immunol. (2004) [Pubmed]
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