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MeSH Review

Tuberculosis, Bovine

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Disease relevance of Tuberculosis, Bovine


High impact information on Tuberculosis, Bovine


Chemical compound and disease context of Tuberculosis, Bovine

  • Group 2 animals were selected from herds undergoing routine surveillance for bovine tuberculosis and contained standard SICTT reactor cattle (PPD-bovine exceeding that of PPD-avian by at least 4mm) and non-reactors [9].
  • Factors identified as possibly involved in increasing the risk of bovine tuberculosis in the Veneto Region were the presence of mixed (dairy and beef) enterprises (OR = 4.9, P = 0.001) and of cattle purchase (OR = 5.8; P = 0.003) [10].
  • The purpose of this project was to determine the effect of dexamethasone (DEX) treatment of tuberculous cows on antigen-stimulated gamma-interferon (gamma-IFN) production in a commercial Mycobacterium bovis gamma-interferon test (gamma-IFN test) developed for diagnosis of bovine tuberculosis [11].
  • Preliminary evaluation of a simple method for detection of bovine tuberculosis: the glutaraldehyde test [12].
  • It is recommended that Lowenstein-Jensen with pyruvate (but without glycerol), Stonebrink's, modified Middlebrook 7H11 and tuberculosis bovine blood agar should be considered the media of choice for the primary isolation of M. bovis [13].

Gene context of Tuberculosis, Bovine


Analytical, diagnostic and therapeutic context of Tuberculosis, Bovine

  • A field trial on a country-wide basis was undertaken to compare the specificity for bovine tuberculosis of single and comparative tuberculin tests in cattle using either Weybridge human or Weybridge bovine PPD [19].


  1. Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and interleukin-2 for protection against bovine tuberculosis. Wedlock, D.N., Vesosky, B., Skinner, M.A., de Lisle, G.W., Orme, I.M., Buddle, B.M. Infect. Immun. (2000) [Pubmed]
  2. Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis. Vordermeier, H.M., Simsova, M., Wilkinson, K.A., Wilkinson, R.J., Hewinson, R.G., Sebo, P., Leclerc, C. Infect. Immun. (2004) [Pubmed]
  3. AhpC, AhpD, and a secreted 14-kilodalton antigen from Mycobacterium avium subsp. paratuberculosis distinguish between paratuberculosis and bovine tuberculosis in an enzyme-linked immunosorbent assay. Olsen, I., Tryland, M., Wiker, H.G., Reitan, L.J. Clin. Diagn. Lab. Immunol. (2001) [Pubmed]
  4. The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Skinner, M.A., Wedlock, D.N., de Lisle, G.W., Cooke, M.M., Tascon, R.E., Ferraz, J.C., Lowrie, D.B., Vordermeier, H.M., Hewinson, R.G., Buddle, B.M. Infect. Immun. (2005) [Pubmed]
  5. Distinct response kinetics of gamma interferon and interleukin-4 in bovine tuberculosis. Rhodes, S.G., Palmer, N., Graham, S.P., Bianco, A.E., Hewinson, R.G., Vordermeier, H.M. Infect. Immun. (2000) [Pubmed]
  6. CD80 and CD86, but not CD154, augment DNA vaccine-induced protection in experimental bovine tuberculosis. Maue, A.C., Waters, W.R., Palmer, M.V., Whipple, D.L., Minion, F.C., Brown, W.C., Estes, D.M. Vaccine (2004) [Pubmed]
  7. A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis. Skinner, M.A., Ramsay, A.J., Buchan, G.S., Keen, D.L., Ranasinghe, C., Slobbe, L., Collins, D.M., de Lisle, G.W., Buddle, B.M. Immunology (2003) [Pubmed]
  8. An update on bovine tuberculosis programmes in Latin American and Caribbean countries. de Kantor, I.N., Ritacco, V. Vet. Microbiol. (2006) [Pubmed]
  9. The effect of the tuberculin test and the consequences of a delay in blood culture on the sensitivity of a gamma-interferon assay for the detection of Mycobacterium bovis infection in cattle. Gormley, E., Doyle, M.B., McGill, K., Costello, E., Good, M., Collins, J.D. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  10. A case-control study on bovine tuberculosis in the Veneto Region (Italy). Marangon, S., Martini, M., Dalla Pozza, M., Neto, F. Prev. Vet. Med. (1998) [Pubmed]
  11. Effect of dexamethasone treatment of tuberculous cattle on results of the gamma-interferon test for Mycobacterium bovis. Goff, B.S. Vet. Immunol. Immunopathol. (1996) [Pubmed]
  12. Preliminary evaluation of a simple method for detection of bovine tuberculosis: the glutaraldehyde test. de Kantor, I.N., Lopez, B., Torres, P., Nader, A., Garcia, V. Zentralblatt Veterinarmedizin Reihe B (1993) [Pubmed]
  13. Comparison of media used for the primary isolation of Mycobacterium bovis by veterinary and medical diagnostic laboratories. Corner, L.A., Nicolacopoulos, C. Aust. Vet. J. (1988) [Pubmed]
  14. Diagnostic implications of antigen-induced gamma interferon, nitric oxide, and tumor necrosis factor alpha production by peripheral blood mononuclear cells from Mycobacterium bovis-infected cattle. Waters, W.R., Palmer, M.V., Whipple, D.L., Carlson, M.P., Nonnecke, B.J. Clin. Diagn. Lab. Immunol. (2003) [Pubmed]
  15. Comparison of the specificity of human and bovine tuberculin PPD for testing cattle. 2. South-eastern England. Lesslie, I.W., Herbert, C.N., Barnett, D.N. Vet. Rec. (1975) [Pubmed]
  16. A review of tuberculosis science and policy in Great Britain. Reynolds, D. Vet. Microbiol. (2006) [Pubmed]
  17. Differentiation between Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle by using recombinant mycobacterial antigens. Buddle, B.M., Parlane, N.A., Keen, D.L., Aldwell, F.E., Pollock, J.M., Lightbody, K., Andersen, P. Clin. Diagn. Lab. Immunol. (1999) [Pubmed]
  18. Use of the polymerase chain reaction for diagnosing bovine tuberculosis in Panama. Cedeño, I., de Obaldía, R., Sanjur, O., Bayard, V., Ortega-Barría, E., Escobar, C. Rev. - Off. Int. Epizoot. (2005) [Pubmed]
  19. Comparison of the specificity of human and bovine tuberculin PPF for testing cattle. 3. National trial in Great Britain. Lesslie, I.W., Herbert, C.N. Vet. Rec. (1975) [Pubmed]
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