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Gene Review:

AFAP1 - actin filament associated protein 1

Gallus gallus

Clump, D.A. et al., Flynn, D.C. et al., Jin, J.P. et al.

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High impact information on AFAP1

Calponin is an actin filament-associated protein found in smooth muscle and non-muscle cells [1].
Both AFAP-110 and a brain specific isoform called AFAP-120 (collectively referred to as AFAP) exist at high levels in chick embryo brain [2].

Analytical, diagnostic and therapeutic context of AFAP1

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate [3].
Western blot analysis indicated that concentrated expression of AFAP correlates well with the AFAP-120 isoform, which appears to be a splice variant of AFAP-110 [2].

References

A role for serine-175 in modulating the molecular conformation of calponin. Jin, J.P., Walsh, M.P., Sutherland, C., Chen, W. Biochem. J. (2000) [Pubmed]
Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain. Clump, D.A., Clem, R., Qian, Y., Guappone-Koay, A., Berrebi, A.S., Flynn, D.C. J. Neurobiol. (2003) [Pubmed]
Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate. Flynn, D.C., Leu, T.H., Reynolds, A.B., Parsons, J.T. Mol. Cell. Biol. (1993) [Pubmed]

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