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Gene Review

AFAP1  -  actin filament associated protein 1

Gallus gallus

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High impact information on AFAP1

  • Calponin is an actin filament-associated protein found in smooth muscle and non-muscle cells [1].
  • Both AFAP-110 and a brain specific isoform called AFAP-120 (collectively referred to as AFAP) exist at high levels in chick embryo brain [2].

Analytical, diagnostic and therapeutic context of AFAP1


  1. A role for serine-175 in modulating the molecular conformation of calponin. Jin, J.P., Walsh, M.P., Sutherland, C., Chen, W. Biochem. J. (2000) [Pubmed]
  2. Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain. Clump, D.A., Clem, R., Qian, Y., Guappone-Koay, A., Berrebi, A.S., Flynn, D.C. J. Neurobiol. (2003) [Pubmed]
  3. Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate. Flynn, D.C., Leu, T.H., Reynolds, A.B., Parsons, J.T. Mol. Cell. Biol. (1993) [Pubmed]
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