Gene Review:
DAB1 - Dab, reelin signal transducer, homolog 1...
Gallus gallus
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Disease relevance of DAB1
- We have isolated two alternatively spliced variants of Dab1 from chick retina, an early form (chDab1-E) expressed in undifferentiated cells and a late form (chDab1-L) expressed in amacrine and ganglion cells [1].
High impact information on DAB1
- A key difference between the two forms is the exclusion in chDab1-E of two Src-related tyrosine kinase recognition sites implicated in Reelin-mediated Dab1 tyrosine phosphorylation [1].
- Alternative splicing modulates Disabled-1 (Dab1) function in the developing chick retina [1].
References
- Alternative splicing modulates Disabled-1 (Dab1) function in the developing chick retina. Katyal, S., Godbout, R. EMBO J. (2004) [Pubmed]
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