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Gene Review

RELN  -  reelin

Gallus gallus

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High impact information on RELN

  • A key difference between the two forms is the exclusion in chDab1-E of two Src-related tyrosine kinase recognition sites implicated in Reelin-mediated Dab1 tyrosine phosphorylation [1].
  • Reelin was highly expressed in the olfactory bulb and in subpial neurons in the marginal zone of the cerebral cortex [2].
  • Comparison of the deiodinase protein distribution with the expression of TH-responsive proteins involved in cell migration (reelin, disabled protein 1 and tenascin-C) allows speculating about the effect of this spatiotemporal distribution pattern on cerebellar cell communicative pathways [3].

Biological context of RELN

  • We propose that alternative splicing of chDab1 represents an effective and flexible way of regulating the Reelin-Dab1-signaling pathway in a mixed cell population, by ensuring that secreted Reelin activates the signaling cascade only in target neuronal cells [1].

Analytical, diagnostic and therapeutic context of RELN


  1. Alternative splicing modulates Disabled-1 (Dab1) function in the developing chick retina. Katyal, S., Godbout, R. EMBO J. (2004) [Pubmed]
  2. Reelin mRNA expression during embryonic brain development in the chick. Bernier, B., Bar, I., D'Arcangelo, G., Curran, T., Goffinet, A.M. J. Comp. Neurol. (2000) [Pubmed]
  3. Role of spatiotemporal expression of iodothyronine deiodinase proteins in cerebellar cell organization. Verhoelst, C.H., Roelens, S.A., Darras, V.M. Brain Res. Bull. (2005) [Pubmed]
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