Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

BBRF3 - glycoprotein M

Human herpesvirus 4

Becker, Y. et al., Lake, C.M. et al., Lake, C.M. et al.

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Disease relevance of BBRF3

The remaining glycoproteins which associated with gN were products of the BBRF3 ORF of EBV, which encodes the EBV gM homolog [1].

High impact information on BBRF3

The Epstein-Barr virus (EBV) glycoproteins N and M (gN and gM) are encoded by the BLRF1 and BBRF3 genes [2].
Differential expression of Epstein-Barr virus (EBV) genes BBRF3, BILF1, and BMRF2 in EBV-transformed lymphoblastoid lines from ataxia-telangiectasia patients [3].
The A-T line L-15 differed from L-6 and the other cell lines in that it expressed only one (3.7 kb) RNA species from BILF1 ORF, while ORFs BBRF3 and BMRF2 were not expressed [3].

Chemical compound and disease context of BBRF3

The Epstein-Barr virus (EBV) gN homolog BLRF1 encodes a 15-kilodalton glycoprotein that cannot be authentically processed unless it is coexpressed with the EBV gM homolog BBRF3 [1].

References

The Epstein-Barr virus (EBV) gN homolog BLRF1 encodes a 15-kilodalton glycoprotein that cannot be authentically processed unless it is coexpressed with the EBV gM homolog BBRF3. Lake, C.M., Molesworth, S.J., Hutt-Fletcher, L.M. J. Virol. (1998) [Pubmed]
Epstein-Barr virus that lacks glycoprotein gN is impaired in assembly and infection. Lake, C.M., Hutt-Fletcher, L.M. J. Virol. (2000) [Pubmed]
Differential expression of Epstein-Barr virus (EBV) genes BBRF3, BILF1, and BMRF2 in EBV-transformed lymphoblastoid lines from ataxia-telangiectasia patients. Becker, Y., Tabor, E., Asher, Y. Leukemia (1988) [Pubmed]

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