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Gene Review:

BLRF2 - putative BLRF2 protein

Human herpesvirus 4

Reischl, U. et al., Nicholas, J. et al., Ragoczy, T. et al., Serio, T.R. et al., Chen, L.W. et al.

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Disease relevance of BLRF2

Here we show that the 21-kDa component of the viral capsid antigen consists of products of two EBV genes, BFRF3 and BLRF2 [1].
After cloning and high-level expression of the BLRF2 open reading frame as DHFR fusion protein in Escherichia coli, the recombinant protein was purified to near homogeneity with the help of continuous elution electrophoresis [2].

High impact information on BLRF2

The response of the BMRF1, BaRF1, and BLRF2 CRBEs was less robust [3].
Some genes, such as BaRF1, BMLF1, and a late gene, BLRF2, are maximally activated by Rta itself in the absence of detectable ZEBRA [4].
The subsequent 18 genes in EBV (BFLF2 to BLRF2, approximate positions 56,000-89,500) are represented in HVS, and the relative positions and orientations of these genes are directly comparable between the two viruses [5].
Open reading frame BLRF2 was identified as the coding region for this protein [2].

References

Two 21-kilodalton components of the Epstein-Barr virus capsid antigen complex and their relationship to ZEBRA-associated protein p21 (ZAP21). Serio, T.R., Angeloni, A., Kolman, J.L., Gradoville, L., Sun, R., Katz, D.A., Van Grunsven, W., Middeldorp, J., Miller, G. J. Virol. (1996) [Pubmed]
Expression and purification of an Epstein-Barr virus encoded 23-kDa protein and characterization of its immunological properties. Reischl, U., Gerdes, C., Motz, M., Wolf, H. J. Virol. Methods (1996) [Pubmed]
Marked variation in response of consensus binding elements for the Rta protein of Epstein-Barr virus. Chen, L.W., Chang, P.J., Delecluse, H.J., Miller, G. J. Virol. (2005) [Pubmed]
Role of the epstein-barr virus RTA protein in activation of distinct classes of viral lytic cycle genes. Ragoczy, T., Miller, G. J. Virol. (1999) [Pubmed]
Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus. Nicholas, J., Cameron, K.R., Coleman, H., Newman, C., Honess, R.W. Virology (1992) [Pubmed]

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