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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

hs6st2  -  heparan sulfate 6-O-sulfotransferase 2

Danio rerio

Synonyms: HS 6-OST-2, HS6ST-2, Heparan-sulfate 6-O-sulfotransferase 2, SO:0000704, fb80f12, ...
 
 
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High impact information on hs6st2

  • In the developing embryo, hs6st is expressed in the brain, the somites, and the fins; the same structures that were affected upon morpholino-mediated functional knockdown [1].
  • Structural analysis of heparan sulfate from wild-type and morpholino antisense 'knockdown' embryos suggests that HS6ST-1 and HS6ST-2 have similar biochemical activity [2].
  • Our finding that HS6ST-2 is required for the branching morphogenesis of the caudal vein is the first in vivo evidence for an essential role of a gene encoding a heparan sulfate modifying enzyme in vertebrate angiogenesis [2].

References

  1. Heparan sulfate 6-o-sulfotransferase is essential for muscle development in zebrafish. Bink, R.J., Habuchi, H., Lele, Z., Dolk, E., Joore, J., Rauch, G.J., Geisler, R., Wilson, S.W., den Hertog, J., Kimata, K., Zivkovic, D. J. Biol. Chem. (2003) [Pubmed]
  2. A unique role for 6-O sulfation modification in zebrafish vascular development. Chen, E., Stringer, S.E., Rusch, M.A., Selleck, S.B., Ekker, S.C. Dev. Biol. (2005) [Pubmed]
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