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Gene Review

sox2  -  SRY (sex determining region Y)-box 2

Danio rerio

Synonyms: SO:0000704, Transcription factor Sox-2, cb236, wu:fb83g04, wu:fc14d07, ...
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High impact information on sox2

  • Knockdown of the d-Asb11 protein altered the expression of neural precursor genes sox2 and sox3 and resulted in an initial relative increase in proneural cell numbers [1].
  • As development progresses, these six B1 sox genes display unique expression patterns that overlap distinctly from one region to another. sox19a expression is widespread in the early neuroectoderm, resembling pan-neural Sox2 expression in amniotes, whereas zebrafish sox2 shows anterior-restricted expression [2].


  1. The novel gene asb11: a regulator of the size of the neural progenitor compartment. Diks, S.H., Bink, R.J., van de Water, S., Joore, J., van Rooijen, C., Verbeek, F.J., den Hertog, J., Peppelenbosch, M.P., Zivkovic, D. J. Cell Biol. (2006) [Pubmed]
  2. Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Okuda, Y., Yoda, H., Uchikawa, M., Furutani-Seiki, M., Takeda, H., Kondoh, H., Kamachi, Y. Dev. Dyn. (2006) [Pubmed]
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